Scribd Logo
Upload

Welcome to Scribd!

  • Pathophysiology of Appendicitis

    Uploaded by

    Eldon Sarmiento
    958 views2 pages
    The document outlines the pathophysiology of appendicitis. It begins with predisposing factors like age and gender that make one more susceptible. Precipitating factors like constipation can cause fecal obstruction in the appendix. This leads to increased pressure in the lumen, vasocongestion, and hypoxia. Bacteria then invade the necrotic appendix, triggering an inflammatory response. If left untreated, the appendix will continue to swell and rupture, causing peritonitis, sepsis, and potentially death. Treatment involves an appendectomy to remove the inflamed appendix before this progression.

    Original Description:

    Original Title

    46437230-Pathophysiology-of-Appendicitis

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    DOC, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    The document outlines the pathophysiology of appendicitis. It begins with predisposing factors like age and gender that make one more susceptible. Precipitating factors like constipation can cause fecal obstruction in the appendix. This leads to increased pressure in the lumen, vasocongestion, and hypoxia. Bacteria then invade the necrotic appendix, triggering an inflammatory response. If left untreated, the appendix will continue to swell and rupture, causing peritonitis, sepsis, and potentially death. Treatment involves an appendectomy to remove the inflamed appendix before this progression.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    958 views2 pages

    Pathophysiology of Appendicitis

    Uploaded by

    Eldon Sarmiento
    The document outlines the pathophysiology of appendicitis. It begins with predisposing factors like age and gender that make one more susceptible. Precipitating factors like constipation can cause fecal obstruction in the appendix. This leads to increased pressure in the lumen, vasocongestion, and hypoxia. Bacteria then invade the necrotic appendix, triggering an inflammatory response. If left untreated, the appendix will continue to swell and rupture, causing peritonitis, sepsis, and potentially death. Treatment involves an appendectomy to remove the inflamed appendix before this progression.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    PATHOPHYSILOGY of APPENDICITIS

    Predisposing factors Precipitating factors:


    - Age: 10 -30 yrs old - Constipation/IBD
    - Gender: male (2:1) - Diet (low fiber)
    LEGEND:

    + Bold - signs & symptoms


    Fecal obstruction + Underlined - medical procedure or
    intervention
    + - not experienced by the patient
    Occlusion of Appendix by Fecalith

    Increased ILP in the appendix

    Vasocongestion Pain

    Hypoxia in the appendix Pyrogens

    Appendix starts to be necrotic; Bacteria invade the appendix Hypothalamus (prostaglandin production)

    Disruption of Cell Membrane of Appendix Fever

    Start of Inflammatory Process

    Mast Cells Activation of the Vomiting Inflammation of Appendix (Appendicitis)


    Center in the Medulla
    Appendectomy
    Bradykinin Prostaglandin Histamine Leukotrienes interleukin - 1
    Stimulation of vagus nerve suppression of sympathetic Tissue Trauma
    vasoconstriction GI function

    vasodilation increase WBC Nausea and vomiting anorexia


    9
    18.30 x 10 /L disruption of cell Nociceptors on the dermis
    increase permeability membrane

    accumulation of WBC start of inflammatory send impulses to the CNS


    to the interstitial compartment process
    swelling of Abdomen
    Phagocytosis pain, & weight loss
    Septic shock: pain, swelling, heat & redness
    swelling Exudates rupture of Peritonitis sepsis if NOT treated - decreased Blood Pressure DEATH
    the swelled appendix (septecemia) - decreased Blood Volume

    Pain Appendectomy with If treated strong antibiotic and RECOVERY


    Explore Laparotomy fluid replacement

    You might also like