Professional Documents
Culture Documents
a. Due to radiation
b. Due to a retrovirus
c. A familial disease
d. Unknown
answer is
d
a. Hypercalcemia
b. Hypocalcemia
c. Hypophosphatemia
d. Hyperkalemia
answer is
a
Which of the following factors complexes with factor
VIII, which is activated to factor VIIIa when released
from the complex
a. Factor XIII
b. High molecular weight kininogen
c. Von Willebrand factor (vWF)
d. Thromboplastin
e. Plasminogen
answer is
c
a. Factor II (prothrombin
b. Factor VII (proconvertin
c. Protein S
d. Factor XIII (fibrin-stabilizing factor
e. Factor X (Stuart-Prower factor
answer is
d
Which of the following causes of anemia is associated
with microcytosis
answer is
e
answer is
d
answer is
b
a. Hemoglobin
b. Ferritin
c. Hemosiderin
d. Myoglobin
e. Transferrin
answer is
e
answer is
d
a. Marrow-depressing effect
b. Directly cytotoxic of platelets
c. Depress megakaryoctye production
d. Immune response in which the platelet is damaged
by complement activation
e. Impair megakaryoctye production
answer is
d
answer is
c
answer is
b
answer is
b
answer is
b
answer is
b
answer is
a
answer is
d
Which mechanism is responsible for
thrombocytopenia in vitamin B12 deficiency
a. Decreased production
b. Maldistribution
c. Accelerated destruction
d. Decreased survival
e. Inherited
answer is
a
Another:
MCQs
………………………………………
20. In which of the following Hematological disorders the polymerase chain reaction
is helpful:
A. Megaloblastic anemia
B. Hemolytic anemia
C. Iron deficiency anemia
D. Hemolytic malignancy
Fibrin/Fibrinogen split products may cause prolongation of the aPTT due to:
A. Deficiency of factors X, V, II or I
B. PT (prothrombin time)
D. Platelet count
Which of the following cells share a common progenotor cells with macrophages?
A-astrocytes.
B-epedendymal cells.
C-microglia
Dmullers fibers
E- oligodendrocytes.
ESR raised in ?
a. SCD
b. multiple myeloma
c. angina petoris
d. thalassemia
Dystrophic
Metastatic
thromboxaneA2 produced by
a. neutrophils
b. macrophage
c. endothelium
d. platelets
L.E. cell is a
a. lymphocyte
b. neutrophil
c. basophil
d. eosinophil
if both parents are sickle cell anaemia patients then the likelyhood of offsprings
having the disease is
a. 25%
b. 50%
c. 75%
d. 100%
ANNGIOTENSINOGEN SECRETED BY
KIDNEY
LIVER
LUNGS
SPLEEN
Basophilic leucocytosis occurs in?
Aml
All
Cml
Cll
1. Haemophillus
2. Staphylococci
3. Neisseria
4. All of above
The globin structure of the major hemoglobin found in human adults is:
A- α2 β2
B- α2 γ2
C- α2 δ2
D- α2 ε2
E- ζ2 ε2
2- Tear drop cells are found at increasing number in all of the following cases,
EXCEPT:
A- Thalassemias.
B- Myelofibrosis.
C- BM tumors.
D- Extramedullary hemopoiesis.
E- None of the above
--The hematologic disease which is expected to be highly seen in spring season is:
A- Glucose 6 phosphate dehydrogenase deficiency.
B- Hereditary pyropoikilocytosis.
C- Hereditary stomatocytosis.
D- Spur cell anemia.
E- All of the above diseases can be seen in spring at the same rate.
A patient with a platelet count of 43x109/L, you noted the presence of platelet
aggregates in his blood film, the most probable cause of his thrombocytopenia is:
A- Idiopathic thrombocytopenia purpura (ITP).
B- This is most probably a manual count but in automated count PLT will be normal.
C- Disseminated intravascular coagulation (DIC).
D- EDTA induced platelet aggregation.
E- Thrombotic thrombocytopenic purpura (TTP).
58-year-old female has a decreased serum iron and TIBC in association with an
increased serum ferritin. These findings are most indicative of:
A- Anemia of chronic disease.
B- Iron deficiency anemia.
C- Sickle cell anemia.
D- Sideroblastic anemia, Hereditary type.
E- Low hepcidin levels.
15- Select the Hb that is the major hemoglobin found in infants with hydrops fetalis:
A- Hb A
B- Hb Lepore
C- Hb H
D- Hb Bart's
E- Hb F
A patient with anemia has an RDW-CV% of 14.0 and an MCV of 120 fL. However,
examination of the blood smear reveals significant anisocytosis. How do you
explain these results?
A- The instrument needs calibration.
B- MCV looks like to be falsely elevated.
C- The RDW is only elevated if there is anisocytosis and a normal MCV.
D- High MCV may causes a falsely normal RDW-CV%.
E- High MCV will not affect RDW-SD.
Another :
Because :
1- S and G and D all have the same electrophoretic
mobility at alkalaine electrophoresis. (:احفظها كالتالي
سجد )س لـS ) ( ج لـG ) و )د لـD ).
2- Hb-H and Hb Bart's both are very fast moving.
Hb-H is composed of 4 beta globin chains, while Hb
Bart's is composed of 4 gamma globin chains, usually
we see both of them in alpha thalassemia (Hb-Barts is
incompatible with life).
السؤالين الجديدين:
7- Kleihauer-Betke test detects:
A- Red cells containing HbF.
B- Red cells containing HbA.
C- Red cells containing HbA2.
D- Red cells containing HbH.
E- Red cells containing Hb constant spring
10- When precursor cells are present in a blood film, they tend
to accumulate in the:
A] Tail.
B] Edges.
C] Multilayer zone.
D] Monolayer zone.
E] Thick area
Another :
What is the most important side effect of heparin?
Heparin can cause thrombocytopenia that in some unlucky patients is associated with
arterial thrombosis.
Measure complete blood counts to monitor for this side effect, which usually occurs on day
3-7 of heparin administration. Discontinue heparin immediately if platelet counts begin to
fall.
How is the effect of heparin monitored?
Heparin is monitored with PTT (partial thromboplastin time), a measure of the internal
coagulation pathway
How is the effect of warfarin monitored?
Warfarin is monitored with the PT (prothrombin time), a measure of the external coagulation
pathway
How do you keep PTT and PT straight?
PTT has a "T" inside, intrinsic, internal coagulation pathway.
PT is the other
Memorize:
Measure heparin with ______
Measure warfarin with ______
Measure heparin with PTT
(Hep to the PTT!)
PT
PTT
Bleeding time
Inheritance
Condition: Hemophilia A
PT: normal
PTT: prolonged (low levels of factor 8)
Bleeding time: normal
Inheritance: X-linked
Condition: Hemophilia B
PT
PTT
Bleeding time
Inheritance
Condition: Hemophilia B
PT: normal
PTT: prolonged (low levels of factor 9)
Bleeding time: normal
Inheritance: X-linked
How do you keep Hemophilia A and B straight?
Hemophilia A is 8A (eight = ate = A) missing factor 8), the more common form.
Hemophilia B is 9B
Condition: vWF deficiency
PT
PTT
Bleeding time
Inheritance
Condition: vWF deficiency
PT: normal
PTT: prolonged
Bleeding time: prolonged
Inheritance: autosomal dominant
PT
PTT
Bleeding time
Inheritance
What else is elevated in terms of labs?
When do you encounter DIC?
What do you see on the blood smear?
Condition: DIC
PT: prolonged
PTT: prolonged
Bleeding time: prolonged
Inheritance: N/A
PT
PTT
Bleeding time
Inheritance
Condition: Liver Disease
PT: Prolonged
PTT: normal or prolonged
Bleeding time: normal
Inheritance: N/A
All factors but 8 are low, you see stigmata of liver disease; no correction with vitamin K
Condition: vitamin K deficiency
PT
PTT
Bleeding time
Inheritance
Condition: vitamin K deficiency
PT: prolonged
PTT: slightly prolonged
Bleeding time: normal
Inheritance: N/A
** low levels of factors 2,7,9,10, proteins C and S; look for neonate who did not receive
prophylactic vitamin K; malabsorption, alcoholism, or prolonged antibiotic use (which kills
vitamin K-producing bowel flora)
MEMORIZE:
PT (extrinsic): 2,5,7,10: increased with warfarin use, vit K deficiency, liver disease
PTT (intrinsic): 8,9,11,12: increased with heparin use, hemophilia A, B, vWF deficiency
PT (extrinsic): 2,5,7,10: increased with warfarin use, vit K deficiency, liver disease
PTT (intrinsic): 8,9,11,12: increased with heparin use, hemophilia A, B, vWF deficiency
Remember that uremia causes a qualitative platelet defect and that vitamin C deficiency and chronic
steroid therapy can cause bleeding tendency with normal coagulation tests.
Remember that uremia causes a qualitative platelet defect and that vitamin C deficiency
and chronic steroid therapy can cause bleeding tendency with normal coagulation tests.