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Pathophysiology of Appendicitis

Modifiable
Non-modifiable
Diet: People whose diet is
Age: 11-20 yrs old low in fiber and rich in refined
Gender: male carbohydrates
(male- female =2 :1) Infections: Gastrointestinal
infections such as Amebiasis,
Hereditary: tumor formation in Bacterial Gastroenteritis,
the opening of the appendix Mumps

Obstruction of the appendix by


(fecalith (hardened stool), lymph
node, tumor, foreign objects)

Increase in pressure inside the


appendix lumen that result to
distention of appendix

Impaired venous return causing hyperemia


(improper O2, and nutrient supply)
Normal bacteria found in appendix begin to invade
(infect) the lining of the wall

Inflammatory Response – body response to the bacterial


invasion in the wall of appendix.
Increased Immune complex (disease plus antibody)
causes swelling of tissue resulting to inflammation of
appendix
S/S: abdominal pain, fever, and increase swelling of
appendix. Vomiting and loss of appetite
Appendectomy,
pain medications
inflammation and infection spread
through the wall of the appendix
Pain- located @ RLQ, causing death of tissue.
causing Guarding, The appendix ruptures due
Vomiting & loss of appetite to increase pressure
(Perforation)

Appendectomy with
explore laparotomy
Perforation (formation of a hole in an organ),
fecal materials exits to peritoneal cavity causing
formation of abscesses (periappendiceal abscess).
Infection can spread throughout the abdomen
(peritoneal cavity)

Bacterial invasion of Peritoneal Cavity causing


inflammation of the membrane that lines the
abdomen peritoneum (Peritonitis)
S/S: swelling of the abdomen, severe pain, and
weight loss

Sepsis (the condition or syndrome caused by the


presence of microorganisms or their toxins in the
tissue or the bloodstream )
Septecemia

IF NOT TREATED IF TREATED

Septic Shock Strong antibiotic


S/S: Medication
• decrease Blood
pressure
• decrease blood Fluid Volume Replacement
volume therapy

COMA
RECOVERY

DEATH