Predisposing Factors

Pathophysiology (Schematic Diagram) of Systemic LupusPrecipitating

Erythematosus, Lupus Nephritis
Factors
>Hereditary (father’s sister), Merck Manual of
Medical Information >Environmental:
>Age (10 yrs), Brunner and Suddarths UV exposure
>Gender (female), Merck Manual of Medical Exposure to foreign antigen
Information (Group A Beta hemolytic Streptococcus, Patient has
history of sore throat, cough and colds)
Second Hand Smoke (father smokes at least 1 stick
per day)

Activate release of auto-

antibody
Binds to self
antigen
Formation of insoluble antigen-antibody complexes
(immune complex)
Immune complexes travel to the different parts of the body
through circulation
Immune complexes becomes trapped in the microcirculation in the skin, joints,
glumerolus, GI tract
Immune complexes activates complement system in those areas inflaming those areas causing damage to the
tissues in those area

Prostagland protaglandin Immune complex Inflammation in the GI Pain

in released by Discoid attach to cells in tract receptors
stimulates immune complex in Rash on the hyaline in GI
the capilliaries in skin right flank Increase Peristalsis tract
cartilage,
hypothalam and in the stimulate
synovial
us to Inflammation in Pruritus
increase membranes in Abdomin
skin Not enough time for
the joints, al
the large intestine
Increas Increased
Leak of fluid to interstitial Stimulation of nerve tenderne
to reabsorb water
es permeability
space of Butterfly endings of pain Immune ss,complex
pain
metabol vascular wall Rash receptors Wate attach to
scale: 7in
cells
ic ry the nephron
out of 10
Stool
s
Demand of
nutrients is greater Joint pain on
than supply knees
Slow Kidney cells
Generali
movements release
zed
prostaglandin
edema
Body Malaise Inflammation in the
Joint pain on
elbows and tissues of the nephron
Fatigue wrist and proliferation of
vascular endothelial
cells
Lysis of
fats and Narrowing of the
proteins glumerolus
Muscl Decreased Decreased Damage
e RBC erythropoie to the
production tin tissue Decreased blood flow
wasti
production to the glumerolus
ng (RBC=3.69g/dL)
Weight Decrease RBC count
loss from Activation of the
release of Renin
(Hgb=9.2g/dL)
19 kgs to Decrease hemoglobin
14 kgs
(Hct=28%) Converts
Ketone Decrease hematocrit angiotensinogen to
(MCHC=32.9g/dL) angiotensin
Ketones Decrease MCHC Converted into
enters (MCH=24.9pg) angiotensin I in the
Decrease MCH liver
Excreted in Water
retention Converted into
(MCV=75.9fL) Vasoconstriction
angiotensin II in the
Ketonuria
Decrease MCV Impaired filtration lungs
function Increased blood
pressure
Generali
zed
edema
 BP=130/90m
Proteinuri mHg
Hematuria
a
Headache

Dizziness

Heartbur Acid contents pass Stimulates

n through esophagus vomiting center
in the brain

Vomiti
ng

LEGEND:
Inflammation in Immune
Predisposing/precipitating factors Endocardium as complexes attach
well as Endocardium as
Disease process
myocardium well as
Manifestations before assessment

Damaged cells release Chest Pain

Manifestations during assessment
prostaglandin that stimulates
nerve endings of pain (Pain scale= 9 of
Abnormal laboratory result
receptors in surrounding 10)
structures of the heart