Professional Documents
Culture Documents
Thomas F. Mauger, MD
Director and Chairman
The Carl M. and Grace C. Baldwin Chair in Ophthalmology
The William H. Havener Eye Institute
The Department of Ophthalmology
The Ohio State University
LAURA SLADOJE
OUTREACH DIRECTOR
CHRISTINA STETSON
PROGRAM COORDINATOR
MICHAEL HOUGHTON
COVER PHOTO
OPHTHALMOLOGY OUTREACH
PHONE | (614) 293-8760
EMAIL | EYE@OSUMC.EDU
RESEARCH FOCUSED ON THE FUTURE
1
Researcher/Clinician Dr. Cebulla with Researcher
Dr. Boru, discussing genetic findings
OCULAR
MELANOMA
TRANSLATING RESEARCH INTO TREATMENT
Mohamed Abdel-Rahman, MD, PhD Many patients envision the sterile to the management of patients with ocular
environment of the laboratory and wonder melanoma. Patients are evaluated by ocu-
Colleen Cebulla, MD, PhD how hours of looking through a microscope lar oncologists Drs. Frederick Davidorf and
Elson Craig, MD relates to their care. The Ohio State Colleen Cebulla, medical oncologists Drs.
Medical Center’s answer can be found Thomas Olencki and Kari Kendra, radia-
Frederick Davidorf, MD at the new OSU Center for Clinical & tion oncologist Dr. Douglas Martin, and
Kari Kendra, MD, PhD Translational Science (CCTS). The CCTS human cancer geneticists Drs. Mohamed
is a Medical Center-wide effort to fast track Abdel-Rahman and Robert Pilarski. By
Thomas Olencki, DO the breakthrough scientific findings from pairing our researchers with our clinicians
the labs to the clinics so patients can benefit and consulting specialists from every field
from OSU’s top-tier research institute. of oncology, the Havener Eye Institute is
able to offer patients a more thorough ap-
The Havener Eye Institute is on the proach to cancer care.
forefront of this initiative with its dynamic,
interdisciplinary ocular melanoma team In the tradition of OSU’s medical pioneers,
working together to end this disease. In the ocular oncologists at the Havener Eye
October 2009, the Havener Eye Institute Institute have always sought to improve
was recognized as one of the leading diagnostic tools and treatments. Until the
centers for the treatment of ocular late 1960s, patients diagnosed with ocular
melanoma at the 1st Annual Ocular melanoma had no choice but to have their
Melanoma Scientific Working Group. eye enucleated (surgically removed).
Then, under the leadership of the late Wil-
The Havener Eye Institute has a long his- liam Havener, OSU Ophthalmology began
tory of using a multi-disciplinary approach the concept of “conservative management”
3
Medication-laden nanobubbles
NANOTECHNOLOGY
TINY PARTICLES The 1966 Oscar award-winning film
Fantastic Voyage took us on a microscopic
NANOFIBERS COMBAT GLAUCOMA
5
Dr. Christoforidis
performing wound
healing research
RESEARCH
REPORT
EXPANDING
The Research Division spans all subspecial- has resulted in appointments in Ophthalmol-
TREATMENT ties of Ophthalmology, and includes not ogy for Dr. Jun Liu, who is experienced in
only the faculty, but also residents, graduate corneal and ocular biomechanics; Dr. Ronald
OPTIONS & students, and medical students. Xu, a specialist in sustained intravitreal drug
DIAGNOSTIC delivery via multifunctional micro/nano
It has been an eventful year, full of promise. particles; and Dr. Yi Zhao, who is an expert
INSTRUMENTS In cooperation with faculty from the Cornea, in the field of micro/nanofabrication for
Retina, and Glaucoma Divisions, we have simulating 3-D ocular tissue structures.
conducted research into many ocular condi-
tions. These collaborations have resulted The Research Division exposes ophthal-
in numerous publications and grant awards mology residents to the scientific research
from the National Institute of Health, the process by involving them with a faculty
Columbus Foundation, the Ohio Lions Eye mentor in either basic science or clinical
Research Foundation, as well as numerous studies. Many residents choose a project
industry awards. that spans all three years of their residency
to allow adequate time for a fully developed
Three research faculty with primary ap- project. They are encouraged to attend the
pointments in Ophthalmology include Dr. Association for Research in Vision and
Mohamed Abdel-Rahman, specializing in Ophthalmology (ARVO) annual meeting and
uveal melanoma and cancer genetics; Dr. present their research. Our ophthalmology
Deborah Grzybowski, who has expertise research faculty also serve as advisors for
in ophthalmic cell culture and intracranial graduate students whose thesis or disserta-
fluid dynamics; and Dr. Cynthia Roberts, an tion involves vision-related research.
ophthalmic engineering specialist. Over the
past few years, a stronger collaboration with Dr. Colleen Cebulla from the Retina Divi-
the Department of Biomedical Engineering sion has been investigating the proteomic
analysis of experimental and human retinal sustained delivery of anti-VEGF therapy via
detachments with proliferative vitreoretinopa- intravitreal injection of micro/nanoparticles
thy (PVR) and potential for therapy. Dr. John with encapsulated drugs for use in treating age-
Christoforidis, also from the Retina Division, related macular edema.
has been evaluating the effect of intravitreal Jun Liu, PhD
anti-VEGF agents on the function of cutaneous Medical students are also given the opportunity
wound healing. to develop a research project of their own, or
to be involved in an ongoing research project.
Many small research projects are supported During the past academic year, two medical
by the Ohio Lions Eye Research Foundation, students received Dorothy M. Bennett and
from which the Department receives an annual Clark L. Bennett Medical Research Scholar-
endowment. A portion of the grant supports ships under the supervision of Dr. Grzybows-
basic research in the Ohio Lions Ophthalmic ki’s project titled, “Retinal capillary angiopathy
Research Laboratory located in the Tzagournis as a biomarker for diabetic systemic disease.”
Medical Research Facility. The lab is directed One student, Benjamin Abramowitz, worked on Ron Xu, PhD
by Dr. Grzybowski and is well equipped for cell a project titled “Swelling Analysis of Biome-
culture-related projects including performing chanical Properties in the Post-LASIK Cornea.”
real-time RT-PCR, ELISA assays, in addition to
IHC, PCR, Western blots, and others. Another For the past year, our dedicated research and
portion of the grant provides additional support clinical faculty have tirelessly pursued new
to the Graduate Fellowship in Eye Research. methods for diagnosis and treatment. The
collaborations between our laboratories and
The Department’s Lions Fellow is Leilei patient care clinics are key to unlocking the
Zhang, MS, who plans to graduate with a PhD treatments of the future.
in June of 2012. Leilei’s research program
has focused on developing a new method for Cynthia Roberts, PhD Yi Zhao, PhD
7
GIVING MAKING A DIFFERENCE
Thom & Nancy Robinson in front
of our donor recognition wall
$10,000 - $49,000 Dr. James Moses Dr. Herbert Bean Dr. Rebecca Kuennen
Jerry Colp Dr. Karl Pappa Dr. A. Gary Bitonte Barbara Landolfi
Phyllis Havener Elizabeth Reese* John Bockoven Dr. Richard Lembach
Dr. Alan Rehmar Dr. John Burns Dr. Carrie Lembach
Drs. Thomas Mauger &
Dr. Carl Shin Dr. Kenneth Cahill Dr. Max & Jean Lerner
L. Carol Laxson
George & Tina Skestos Dr. John Christoforidis Paul Little
Peggy Roberts Laura & Doug Sladoje Dr. Jeffrey & Sue McAdoo
Dr. Landon Colling
Jacob & Zel Yessenow Gina Coman Kathryne McKinney
$5,000 to $9,999 Dennis Corbett Dr. Randy McLaughlin
Dr. C. Patrick Carroll Jill & Karl Milliron
$500 to $999 Albert Covelli
Dr. Henry & Suzanne Croci Dian Montgomery
John Alberini Dr. Elson Craig*
Dr. David Lehmann Lora Moore
Dr. N. Douglas Baker Shannon Culp
John Marakas Skip Murray
Dr. Frederick Davidorf Dr. Elliot Davidoff
Mildred Glover Dr. Jack Dingle Fred & Cheryl Nicely
$2,500 to $4,999 Dr. Thomas Dingle Marlene O’Dair
Dr. Charles & Susan Hickey
Dr. David Adam Dr. Philip O’Donnell
Dr. Christopher Hogan Henry & Elaine DiSalvo
Dr. Louis Bloomberg* Robert Olson
John Jeffries Catherine Fenderson
Dr. Colleen Cebulla Karen Price
Steven Juenger Ruth Fisher
Drs. Jack & Candace Hendershot Trish Rebish
Laurence Karns Dr. Gloria Fleming
Dr. Steven & Stacy Katz Ann Roush
Dr. Alan & Susan Letson Deborah Lanam Dr. Carla Ford
Jill Salerno
William & Lynne Martin Dr. Charles Leone Jr. Margery Forry
T. Dwain Sayre
Dr. Robert McKinlay Tim McNemar Dr. Jill Foster
Grier Schaffer
Dr. Garret & Christina Mouser Dr. William Penland Kelli Fox
Robert & Helenor Smith
Dr. Jeffrey Oehler Richard Poffenbaugh Steve Gifford Morris Stamm
Dr. Dale & Bonnie Solze Paul Ritter Jr. Dr. Richard Golden Christina & Graham Stetson
Dr. Mac Ronning Alicia Green Craig Stevens
$1,000 to $2,499 Michael Sauer Carolyn Greshemer Mike Steyer
Larry & Frances Black Dr. Edward Schechter James & Tally Grossman Dr. Michael Stone
Dr. Mark Gersman Dr. Paul & Lesley Weber Dr. Deborah Grzybowski Dr. Amit Tandon
Bruce & Bridgitt Evans Roy Whipple Lori Hall Dr. David Taylor
Michael & Joyce Hallet Dr. John Wilding Ann Havener Donna Taylor
Dr. Marilyn Huheey Audrey Henry Marlene Tope
Dr. Curtin Kelley $100 to $499 Virginia Hess Dr. Paul Treger
Drs. Frank & Carol Kollarits Dr. J. Geoffrey Allen Mary Katherine Hobbs Lionel & Sandra Waldman
Robert & Danette LaFollette Liz Allison John Hummel & Mary Jayne Fox James Weaner
Dr. Robert Lembach Virginia Armstrong Dr. Gary & Nancy Katz Lisa Williamson
Dr. James & Antoinette Magnuson Dr. William Banks III Rhonda Lee Kitzler Dr. Jeffrey Wincko
Dr. Carl Minning Jr. Dr. Thomas Bates Dr. Marilyn Kosier George Wintringer
*Indicates deceased
9
DR W. THOMAS MARTIN
Thinking thirty years ahead is not some- thalmology. After graduating, he joined his
thing that many people do, but when Dr. father’s Massillon, Ohio comprehensive
W. Thomas Martin first started his oph- ophthalmology practice.
thalmology practice he wanted to show his
appreciation for the fine training that he “Dad was a big-hearted doctor,” said Dr.
had received in the OSU Department of Martin's son John Martin, DDS. “He
Ophthalmology. would rather that his patients get what they
needed than take a paycheck home. He
With that in mind, he purchased life insur- really cared about his patients.”
ance policies for himself and his two chil-
dren and named OSU Ophthalmology as the Dr. Martin really cared about his education
beneficiaries. After 30 successful years in as well. In addition to the matured insurance
practice, he is still happy with his decision. policies, he has made many monetary gifts to
OSU Ophthalmology, totaling over $40,000.
“I wanted to give because of my training,”
said Dr. Martin. “I trained with Dr. Haven- “It is so encouraging to see residents giving
er, who was like a walking dictionary. You back,” said Dr. Alan Letson, Residency Pro-
could be in surgery with him and ask him gram Director. “We are always striving to live
anything. He could answer ophthalmology up to the level of training that Dr. Havener
questions all day.” always gave. Gifts like this make it possible.”
The son of a Northern Ohio ophthal- Dr. Martin is enjoying his much-deserved
mologist, Dr. Martin went to OSU Medical retirement in Norfolk, Virginia where he
School before being selected by OSU Oph- lives with his oldest son, John.
DR GARRET & CHRISTINA MOUSER Donations like the Mousers’ enable the De-
partment to support resident education and
research through the purchase of textbooks
Garret Mouser, MD completed his residency practice in Columbus with satellite offices and equipment.
in 2007. Upon graduation, he joined James in Canal Winchester and Washington Court
Moses, MD, in a thriving ophthalmology House.
OSU President E.
Gordon Gee
PRESIDENT’S CLUB Through their generous contributions, Presi-
dent’s Club members make a lasting impact in
the lives of students, researchers, faculty, and
The President’s Club is a special circle of staff every day. From providing much-needed
friends who share a common passion for and scholarships for students, to creating funds for
pride in Ohio State. They make a meaningful new ground breaking global research initia-
difference at the university by providing lead- tives, President’s Club members are opening a
ership support for academics, health sciences, world of opportunities for Buckeyes to attain
and the arts at The Ohio State University. The academic excellence and positively affect their
vision of the President’s Club is to represent communities and the world.
the largest source of philanthropic support
and volunteer leadership required for The Ophthalmology alumni have been making
Ohio State University to be recognized among a visible difference through the President’s
the world’s truly great universities. Club from the beginning. All of your Presi-
dent's Club donation can be directed to the
The President’s Club was founded in Ophthalmology fund of your choice.
1963 to cultivate a culture of philan-
thropic leadership for The Ohio State President’s Club members are actively
University. It establishes lifelong helping to define Ohio State as the nation’s
relationships with alumni, friends, leading public land-grant university. Take
parents, faculty, staff, and students and your seat in the President’s Club and make a
encourages active involvement in the life of donation to Ophthalmology today!
the university. By eliciting significant finan-
cial support, each year the President’s Club For more information on the President’s Club,
members aid in the realization of current and please contact Barbara Landolfi at (614) 293-
emerging academic priorities. 8760 or email us at eye@osumc.edu.
11
EDUCATION TRAINING TOMORROW’S OPHTHALMOLOGISTS
We also want to recognize all of the residents had papers that were
presented at the ARVO Annual Meeting, including Drs. Vishal Drs. Dupps, Reichel, and Harton
Verma, Rick Whitehead, Andrew Hendershot, and Cedric Pratt.
The 53rd Annual Postgraduate Symposium in
“Metastasis in Small Uveal Melanomas” V Verma, MH Abdel-Rah- Ophthalmology was held on March 5th, 2010
man, CM Cebulla, FH Davidorf. with over 150 participants in attendance. This
year’s course directors, Cynthia Roberts,
“Utility of the Convergence Insufficiency Symptom Survey in a PhD, and Paul Weber, MD, brought numerous
Tertiary Care Center” G Whitehead, DL Rogers, M McGregor, A accomplished and knowledgeable speakers
Serna. together to discuss Ocular Imaging, including
William Dupps Jr., MD, PhD (Cleveland
“Cataract Surgery Simulators in the Training of Ophthalmology Resi- Clinic), Paul Harton Jr., MD (Harbin Eye
dents” AJ Hendershot, AM Mahmoud, TF Mauger. Clinic), Elias Reichel, MD (Tufts University
School of Medicine), Andrea Sawchyn, MD
“The Effect of Intravitreal Pegaptanib, Bevacizumab and Ranibi- (Wills Eye Institute), Mitchell Weikert, MD,
zumab on Blood Vessel Formation During Cutaneous Wound Healing MS (Baylor College of Medicine), Colleen
in a Rabbit Model” JB Christoforidis, R Ricketts, S Bean, C Pratt, J Cebulla, MD, PhD (OSU), Jennifer Lewis,
Pierce, MB Wells, K La Perle. PhD (OSU), Thomas Mauger, MD (OSU).
GRADUATING RESIDENTS
We wish our graduating residents well as they embark on new ventures.
Cedric Pratt, DO remains at the Havener Eye Institute to complete a two-
year retina fellowship. Wendy Smith, MD matched with the National In-
stitute of Health for a uveitis fellowship. Rick Whitehead, MD has been
selected for a pediatric ophthalmology fellowship at Indiana University.
Katie Baston, MD joined a comprehensive ophthalmology private prac-
tice in El Paso, TX. Landon Colling, MD has moved to Lynchburg, VA
to practice comprehensive ophthalmology in a private practice.
13
Back Row: Drs. Cloud, Davis, Verma, Buzzacco, Costin, Whitehead, Lawhon, Pratt, Colling
Front Row: Drs. Wall, Tung, Smith, Olson, Vaccarella, Kukuyev, Baston, Chheda
RESIDENTS
FIRST-YEAR RESIDENT CLASS (2009-2012)
Dominic Buzzacco, MD
Adam Cloud, MD
Bryan Costin, MD
Irene Tung, MD
Leah Vaccarella, MD
Palak Wall, MD
FELLOWS
Ashley San Filippo, MD received her medical degree from the
Northeastern Ohio Universities Colleges of Medicine and phar-
macy in Rootstown, OH and her ophthalmology residency at the
SECOND-YEAR RESIDENT CLASS (2008-2011) University of Missouri in Kansas City, MS. Now that she has con-
Lena Chheda, MD cluded her Glaucoma Fellowship here at the Havener Eye Institute,
Aaron Davis, MD she has joined a private practice here in Columbus.
Alla Kukuyev, MD
William Lawhon, MD Andrew Hendershot, MD completed his Medical degree, ophthal-
Cate Olson, MD mology residency, and his cornea fellowship all at The Ohio State
Vishal Verma, MD University. Now, he plans to stay on at the Havener Eye Institute
as a faculty member in the Cornea Division.
THIRD-YEAR RESIDENT CLASS (2007-2010)
Katie Baston, MD Sunday Olatunji, MD attended Chicago Medical School in Chi-
Landon Colling, MD cago, IL where he received his medical doctorate. He completed
Cedric Pratt, DO his ophthalmology residency at the Kresge Eye Institute in Detroit,
Wendy Smith, MD MI and is half-way through a two-year vitreoretinal fellowship at
Rick Whitehead, MD the Havener Eye Institute.
JAMES AUGSBURGER, MD
University of Cincinnati SANFrancisco
University of Cincinnati Chairman Dr. James Augsburger, was our AAO Alumni Reception
first lecturer for the new Davidorf Lectureship Series. Dr. Augs-
burger spoke about Genetic Prognostication of Metastasis in Uveal Each year the OSU Havener Eye Institute holds a special
Melanoma. “As a national expert in the field of ocular melanoma, reception in honor of the many excellent ophthalmologists
Dr Augsburger has an incredible breadth of knowledge,” said Sun- that hail us as their Alma Mater. This anticipated event
day Olatunji, MD, a first-year retina fellow. “His talk highlighted coincides with the American Academy of Ophthalmology
more than the new genetic classification techniques; he really (AAO) Annual Meeting, which brings together ophthal-
delved into the subject and what it could mean for patients with mologists from across the nation and around the world.
ocular cancer.”
The 2009 Alumni Reception found us in San Francisco,
CA. A perfect day and a spectacular view from the top
of the Hotel Nikko greeted Havener alumni, faculty, and
colleagues as we celebrated both our alumni and the OSU
Department of Ophthalmology’s 80th Anniversary.
15
EYECARE PERSONALIZED CARE
ANDREA SAWCHYN, MD
Glaucoma
Dr. Sawchyn graduated summa cum
laude from the University of Notre Dame
with a BS in Science Preprofessional
Studies. For both her medical degree
and ophthalmology residency she at-
tended The Ohio State University. She
ELECTRONIC RECORDS continued her training with a glaucoma
fellowship at Wills Eye Institute in Phila-
In addition to our move to our new Eye and Ear Institute last delphia, PA. Dr. Sawchyn will add new
year we also migrated onto Epic-based electronic medical diagnostic and therapeutic modalities to
records (EMR). This is potentially a difficult and burdensome the division, as well as a passion to help
transition for all physicians, but particularly for ophthalmolo- patients.
gists due to our unique documentation and imaging needs.
17
ANTERIOR
SEGMENT Rebecca Kuennen, MD
Division Director
Andrew Hendershot, MD
The Anterior Segment Division continues The division mentored multiple resident and
to be actively involved with clinical care, fellow research projects this past year. Such
education, research, and service. Dr. Andrew projects included the use of a cataract surgery
Hendershot recently joined as a new faculty simulator in resident training, comparison of Richard Lembach, MD
member after completing his cornea fellow- ultrasonographic measurements of corneal
ship in June 2010. Dr. Randy McLaughlin aggregate modulus in normal and post-LASIK
and Dr. Kelly Kingsbury continue to provide patients, measurement of corneal epithelial
optometric care including comprehensive thickness in keratoconus using a Fourier do-
evaluations as well as routine and complex main anterior segment OCT, and use of confo-
contact lens services. cal microscopy in diagnosis of Acanthamoeba
and fungal keratitis.
Medical student, resident, and fellow education
continues to be a strong focus in the division The division also had abstracts presented at the
through staffing clinics and surgeries at The 2010 Association for Research in Vision and
Ohio State University Medical Center, Ohio Ophthalmology and Ocular Microbiology and Thomas Mauger, MD
State University Eye and Ear Institute, Colum- Immunology Group meetings. The division Chairman
bus Veterans Administration Outpatient Clinic, is currently conducting clinical trials with
and Nationwide Children’s Hospital. The divi- nepafenac 0.3% in the prevention and treat-
sion staffed over 500 cataract surgeries at the ment of ocular inflammation and pain after
Columbus VA with the residents last year. cataract surgery. The division along with Dr.
Cynthia Roberts will soon be starting a clinical
During the past year, the division had over research trial studying the safety and effective-
16,000 patient office visits and performed ness of the VEGA UV-A system for corneal
over 1,000 cataract surgeries. We performed collagen cross-linking in eyes with keratoco-
114 keratoplasty procedures including nus and post-refractive corneal ectasia. Julie Meier, MD
penetrating keratoplasty, endothelial kerato-
plasty, deep anterior lamellar keratoplasty, The division continues to be involved in
and keratoprosthesis. We also performed medical mission trips to Ghana and Nicara-
61 procedures at Nationwide Children’s gua. Dr. Mauger and Dr. Cate Olson traveled
Hospital including penetrating keratoplasty, to Ghana in February 2010 and performed
keratoprosthesis, anterior segment and ocular cataract surgeries. The division is also ac-
surface reconstructive surgeries, and exami- tively involved with the Columbus Medical
nations under anesthesia. Association Physicians Free Clinic and at the
monthly Havener Eye Institute Free Clinic.
The division continues to be actively involved
in both clinical and basic science research. REBECCA KUENNEN, MD Amit Tandon, MD
GLAUCOMA
19
Steven Katz, MD
Division Director
David Hirsh, MD
NEURO-OPHTHALMOLOGY The Neuro-ophthalmology service continues Women’s Health, Eye, Anatomical Record, and
to contribute to the departmental mission in Obesity Reviews; an advisor to the Chief of
the core areas of clinical care, teaching, and Space Medicine at NASA Johnson Space Cen-
research. Division faculty are responsible for ter and the Intracranial Hypertension Research
the resident lecture series as well as medical Foundation; as well as being a grant reviewer
student teaching in neuro-ophthalmology. for the Columbus Foundation, the American
Institute of Biological Sciences, the US Army
Susan Benes, MD, with the assistance of David Medical Research and Material Command.
Hirsh, MD, organized the neuro-ophthalmol-
ogy morning lecture series. Drs. Benes and The division is actively enrolling patients into
Hirsh continue to be active clinical instructors the Idiopathic Intracranial Hypertension Treat-
and are also regular contributors to the Grand ment Trial. This multicenter, double-blind
Rounds focused in neuro-ophthalmology. randomized placebo-controlled study hopes to
determine if weight reduction and/or low so-
A Pseudotumor Cerebri Center of Excel- dium diet alone or combined with medication
lence was created and is dedicated to the care will benefit patients with idiopathic intracra-
of patients with idiopathic and secondary nial hypertension. The study was proposed
intracranial hypertension. The group will by Neuro-Ophthalmology Research Disease
include neuro-ophthalmology, otolaryngology, Investigator Consortium (NORDIC) and is
neurosurgery, neurology, endocrinology, and sponsored by the National Eye Institute.
biomedical engineers. The group will also
focus on clinical and basic science research to There are currently 7 other clinical trials going
provide better understanding of the underly- on in the division in the areas of multiple scle-
ing etiology as well as more targeted treat- rosis and ocular toxicity of cancer treatments.
ment options. A tissue bank is being created
to collect blood and cerebrospinal fluid from Dr. Cindy Roberts and Dr. Katz are currently
patients for long-term studies. involved in the China Eye Project, an effort to
develop a new surgical procedure to implant a
Many of our division faculty utilize their device for direct optic nerve stimulation.
unique qualifications to serve the community.
Dr. Steven Katz was a reviewer for Journal of STEVEN KATZ, MD
OPHTHALMIC
TOTAL CASES INCLUDED: PATHOLOGY
11 Lens, gross only The Division of Ophthalmic Pathology in sion of Abhik Ray Chaudhury, MD. Weekly
the Department of Ophthalmology provides review sessions were conducted that included
42 Eye, gross only support to faculty, residents, and students faculty, residents, and students from both
when preparing presentations, publications, departments. A joint report for each case was
13 Foreign body, gross only and for research projects. The Division has generated and filed.
an extensive archive of pathology cases and
1 Nerve biopsies, eye microscopic and photographic equipment For the academic Fiscal Year July 1, 2009
available to support these activities to June 30, 2010, 581 cases were examined,
54 Conjunctival mass, tumor, cyst reported, and filed in the division archives of
All ophthalmic pathology specimens from ophthalmic pathology.
71 Cornea, whole our Department are processed in The Divi-
sion of Neuropathology under the supervi- ELSON CRAIG, MD
84 Cornea, biopsies
30 Enucleation
4 Evisceration
1 Skin, excision
6 Eye, biopsies
21
OCULOPLASTICS
The Oculoplastic Division is staffed and surgery
is performed at the OSU Eye & Ear Institute, the
and neck cancer. With more aggressive resec-
tions, the multidisciplinary reconstruction of these
University Hospital Clinics, the Columbus and patients is increasingly challenging.
Dayton VAs, and Nationwide Children’s Hospital
with active involvement of all resident classes. Dr. Kenneth Cahill is on the executive commit-
Didactic lectures are provided for ophthalmology tee of the International Thyroid Eye Disease
residents and those in ENT, plastic surgery, and Study Group. He also serves on the American
family medicine. Medical student education is Academy of Ophthalmology Ophthalmic Tech-
supported with lectures in their core curriculum, nology Assessment Committee.
physical diagnosis instruction, clinical rotations, Kenneth Cahill, MD
and participation in research projects. We have made local and national presentations
and written eight book chapters covering thera-
Our American Society of Ophthalmic Plastic peutic and cosmetic botulinum toxin, cosmetic
and Reconstructive Surgery (ASOPRS) fellow- tissue fillers, blepharoplasty surgery, ptosis,
ship training program complements residency entropion, ectropion, trichiasis, eyelid recon-
training. Our recent graduate fellow, Dr. Kevin struction, bioengineered tissue grafts, thyroid
Michels, received the annual fellow teaching eye disease, anophthalmic socket reconstruc-
award. tion, brow lifts, forehead rejuvenation, and
tissue adhesives.
Dr. Steven Katz continues his diligent work
with the residents by overseeing the hospital Ongoing research projects include lacrimal Steven Katz, MD
ward and emergency room consult service. outflow system imaging, botulinum toxin ef-
ficacy, new techniques of tissue filler delivery,
In 2009, Dr. Katz was a founding member of the minimally invasive facial surgery, facial anato-
Comprehensive Skull Base Center at the James my, and treatment of orbital lymphangiomas.
Cancer Hospital. The group is dedicated to
advancing the care of patients with complex head KENNETH CAHILL, MD
ers, MD, Don Bremer, MD, Cybil Cassady, MD, We are engaged in fMRI research for nystagmus,
Richard Golden, MD, Julie Lange, MD, Mary corneal pachymetry, amblyopia, convergence in-
Lou McGregor, MD, and David Rogers, MD. The sufficiency, and congenital cataracts. The group
clinic is staffed by one first-year and two second- is involved in three multicenter trials on retinopa-
year ophthalmology residents and two optom- thy of prematurity and is a participating center for
etrists. We are very active surgically, consistently PEDIG.
Top: Drs. G. Rogers, D.
Rogers, and Bremer showing improved numbers in the surgery center.
With the support of Nationwide Children's Hospi-
Bottom: Drs. Cassady, tal, we have increased laboratory and clinical space
Golden, and McGregor In addition to clinical eye care, the division sup-
and equipment to better serve our young patients.
ports research and teaching programs that ensure
Newest faculty, Julie delivery of the highest quality pediatric care. The
It continues to be our goal to be a leader in the
Lange, MD with residents division participates in both funded and unfunded
research of fMRI and changes to the visual
research. Several amblyopia protocols and a cortex in patients with amblyopia and nystagmus.
randomized nasolacrimal duct study are being PEDIG has recognized our previous research
conducted in association with the Pediatric Eye with sinemet and amblyopia and has just com-
Disease Investigator Group (PEDIG). Drs. Don pleted the first multicenter study in amblyopia
Bremer and Rick Golden are the Principal Inves- involving the treatment of older children using a
tigators for these PEDIG trials. similar levodopa-carbidopa combination.
Larry Leguire, PhD, continues to work with the I am very pleased with the progress of our divi-
division conducting functional MRI research with sion and its continued success.
an interest in congenital ocular motor nystagmus.
An eye tracker in the MRI scanner has been GARY ROGERS, MD
23
Refractive patient about
to undergo all-laser LASIK
David Castellano, MD
Division Director
Amit Tandon, MD
Rebecca Kuennen, MD
The Retina Division faculty includes Colleen manager Laura Sladoje and clinical trial 2009), contributed to imaging for clinical
Cebulla, MD, PhD, John Christoforidis, MD, coordinators Jill Salerno, Jill Milliron, and trials as well as other trials performed by
Susie Chang, MD, Fred Davidorf, MD, Paul Kathy McKinney, the division was actively other departmental divisions. The imaging
Kurz MD and Alan Letson, MD. involved in clinical trials sponsored by service includes high resolution color and
National Eye Institute (AREDS 2, CATT), fluorescein angiography, ICG angiography,
Dr. Cebulla joined the faculty in September DRCR.net, and industry-sponsored trials Fundus Autofluorescence, high resolution
2009 after having completed fellowships in from Genentech, Allergan, Alcon and Glax- anterior and posterior segment ocular and
Ocular Oncology and Vitreoretinal Surgery oSmithKline involving areas of wet AMD, orbital ultrasonography, time domain OCT,
at Bascom Palmer Eye Institute. She brings diabetic macular edema, retinal detachment, and spectral domain OCT.
experience in ocular melanoma and will be cataract and macular edema, and topical
doing both basic science research as well VEGF inhibitors. Dr. Cebulla obtained grant The division maintained its teaching activ-
as working with Dr. Davidorf on the ocular funding for her work in ocular melanoma ity by supporting two retinal fellows Mike
oncology service. and PVR and has been collaborating with Wells, MD, and Sunday Olatunji, MD, and
Mohamed Abdel-Rahman, MD, PhD, in the working with residents in their first- and
Patient care activity included over 8,500 pa- lab. Dr. Davidorf and Dr. Abdel-Rahman second-year retina rotations. Medical
tient visits, with over 6,200 diagnostic imag- continue their research in ocular melanoma students also rotate on the service. Retina
ing procedures for the division. The surgical molecular genetics. Dr. Christoforidis has faculty deliver weekly retina lectures to
retina team performed over 800 major vitreo- been working on lab projects related to residents and hold imaging conferences
retinal procedures. Over 1600 intravitreal VEGF inhibitors and wound healing as well with residents and fellows. The retina fac-
injections were given for wet AMD and other as high resolution MRI for ocular imaging. ulty also serves as preceptors for resident
causes of CNV and macular edema. research projects and is active in the cur-
Scott Savage and his team of retinal photog- riculum of the College of Medicine.
This past year was also another strong raphers, Stephen Shelley, Amanda Barnett,
year for research. Led by clinical research and PJ Fish (who joined the team in autumn ALAN LETSON, MD
Alan Letson, MD Colleen Cebulla, MD, PhD Susie Chang, MD John Christoforidis, MD
Division Director
Frederick Davidorf, MD Paul Kurz, MD L. Carol Laxson, MD, PhD Michael Wells, MD
25
GRANTS NEW FRONTIERS IN MEDICINE
NEURO-OPHTHALMOLOGY
CORNEA Title: Capillary changes in Fabry disease
Sponsor: Genzyme Corporation
Title: Corneal crosslinking in keratoconus: Crosslinking for Principal Investigator: Deborah Grzybowski, PhD
corneal ectasia after refractive surgery. Co-Investigators: Alan Letson MD
Principal Investigator: Richard Lembach MD
Co-Investigators: David Castellano MD Title: Fabry registry
Sponsor: Genzyme Corporation
Title: Clinical Safety and Efficacy Comparison of Nevanac 0.1% to Principal Investigator: Deborah Grzybowski PhD
Vehicle following Cataract Surgery in Diabetic Retinopathy Patients.
Sponsor: Alcon Title: A Phase II, Double-Blind, Randomized, Placebo-Controlled
Principal Investigator: Thomas Mauger MD Study to Assess the Efficacy of AZD6244 (Hyd-Sulfate) in Com-
Co-Investigators: Alan Letson MD, Frederick Davidorf MD, bination with Docetaxel, Compared with Docetaxel Alone, in 2nd
Line Patients with KRAS Mutation Positive Locally Advanced or
John Christoforidis MD, Susie Chang MD, Paul Kurz MD
Metastatic Non Small Cell Lung Cancer (Stage IIIB-IV)
Sponsor: Astra Zeneca
Title: Clinical evaluation Nepafenac ophthalmic suspension,
Principal Investigator: Miguel Villalona MD
0.3% for prevention and treatment ocular inflammation and and
Co-Investigators: Steven Katz MD
pain after cataract surgery
Sponsor: Alcon Title: A Multicenter, Double-blind Randomized Placebo-con-
Principal Investigator: Thomas Mauger MD trolled Study of Weight Reduction and/or Low Sodium Diet plus
Co-Investigators: Rebecca Kuennen MD Acetazolamide vs Diet plus Placebo in Subjects with idiopathic
Intracranial Hypertension with Mild Visual Loss.
Sponsor: National Institutes of Health
GLAUCOMA Principal Investigator: Steven Katz MD
Title: A retrospective, comparative, case series evaluating the Title: Phase 3, randomized, open-label study of the efficacy and
alternation flicker technology and standard stereo photography safety of PF-02341066 versus standard of care chemotherapy
viewing as methods for determining change on photographs of the (pemetrexed or docetaxel) in patients with advanced non-small
optic nerve head. cell cancer (NSCLC) harboring a translocation or inversion event
Sponsor: EyeIC Inc. involving the Anaplastic lymphoma kinase (ALK) gene locus
Principal Investigator: Paul Weber MD Sponsor: Pfizer
Co-Investigators: Amit Tandon MD, Gloria Fleming MD, M Principal Investigator: Greg Otterson MD
Iyad Azrak MD, Michael Wells MD, Landon Colling MD Co-Investigators: Steven Katz MD
27
PUBLICATIONS SHOWING RESULTS
Authors: Abdel-Rahman MH, Boru G, Massengill J, Salem Authors: Bajenaru L, Pina Y, Murray T, Cebulla C, Feuer WJ,
MM, Davidorf FH Jockovich ME, Marin-Castano ME
Title: MET oncogene inhibition as a potential target of therapy Title: Gelatinase Expression and Modulation in Retinoblastoma
for uveal melanomas Journal: Investigative Ophthalmology & Visual Science
Journal: Investigative Ophthalmology & Visual Science Pages: 51(6):2860-4
Pages: 51(7):3333-9 Date: January 2010
Date: July 2010
Authors: Piña Y, Boutrid H, Murray TG, Jager MJ, Cebulla CM,
Authors: Abdel-Rahman MH, Pilarski R, Ezzat S, Sexton J, Schefler A, Ly LV, Alegret A, Celdran M, Feuer W, Jockovich M
Davidorf FH Title: Impact of tumor-associated macrophages in LH(BETA)
Title: Cancer family history characterization in an unselected T(AG) mice on retinal tumor progression: relation to macrophage
cohort of 121 patients with uvealmelanoma. subtype
Journal: Familial Cancer Journal: Investigative Ophthalmology & Visual Science
Pages: 9(3):431-8 Pages: 51(5):2671-7
Date: September 2010 Date: May 2010
Authors: Yeh S, Cebulla CM, Witherspoon SR, Emerson GG, Authors: Leng T, Cebulla CM, Schefler AC, Murray TG
Emerson MV, Suhler EB, Albini TA, Flaxel CJ Title: Focal periocular carboplatin chemotherapy avoids system-
Title: Management of fluocinolone implant dissociation during ic chemotherapy for unilateral, progressive retinoblastoma
implant exchange. Journal: Retina
Journal: Archives of Ophthalmology Pages: 30(4 Suppl):S66-8
Pages: 127:1218-21 Date: April 2010
Date: September 2009
Authors: Cebulla C, Ruggeri M, Murray TG, Feuer WJ, Hernan-
Authors: Boutrid H, Pina Y, Cebulla C, Feuer WJ, Lampidis TJ, dez E
Jockovich ME, Murray T Title: Spectral domain optical coherence tomography in a murine
Title: Increased Hypoxia following Vessel Targeting in a Murine retinal detachment model
Model of Retinoblastoma Journal: Experimental Eye Research
Journal: Investigative Ophthalmology & Visual Science Pages: 90(4):521-7
Pages: 50:5537-43 Date: April 2010
Date: December 2009
Author: Mauger T
Title: What should I do for a patient who wears soft contact
lenses and complains of dry itchy eyes?
Book: Curbside Consultation in Cornea and External Disease
Editors: Price FW, Price MO, Letko E, Chang DF
Publisher: Slack Inc.
Pages: Chapter 38
Date: April 2010
29
PRESENTATIONS
Dr. Fleming giving a lecture in the conference
room at the new OSU Eye & Ear Institute
SHARING DISCOVERIES
Abdel-Rahman AM. “Clinical Cancer Genetics.” Children Cancer Hos- Grzybowski DM. “Arachnoid pathways for CSF absorption.” Hydro-
pital of Egypt. Cairo, Egypt. July 2009. cephalus 2009 NIH Workshop, Improving Outcomes in Hydrocephalus:
Bridging the Gap Between Basic Science and Clinical Management.
Castellano D. “The Aging of the Eye/Cataracts.” Dublin Retirement Baltimore, MD. September 2009.
Village. July 2010
Grzybowski DM, Long AC. “Retinoid signaling pathway proteins in
Cebulla CM, Sisk RA, Markoe AM, Dubovy SR, Murray TG. “Com- human arachnoid membrane: Role in regulating intracranial pressure,”
bined Pars Plana Vitrectomy, Cataract Extraction and Endolaser Ablation International Society for Hydrocephalus and CSF Disorders, Baltimore,
for Treated Uveal Melanoma.” International Society of Ocular Oncol- MD, September 2009.
ogy. Cambridge, UK. September 2009
Kim B, Grzybowski DM, Weber PA, Roberts CJ, Zhao Y. “Electrospun
Cebulla CM, Ruggeri M, Murray TG, Hernandez E. “Optical Coherence
Micro/Nanofiber Assisted In Vitro Construction of Trabecular Meshwork
Tomography in a Murine Retinal Detachment Model.” Leeds University
for Glaucoma Investigation.” 13th International Conference on Miniatur-
Molecular Medicine Institute. Leeds, UK. September 2009.
ized Systems for Chemistry and Life Sciences. Jeju Island, Korea. 2009.
Cebulla CM. “Scarlet and Grey Intraocular Tumors.” Columbus Eye
Ear Nose Throat Society. Columbus, OH. October 2009. Katz SE. “Ocular and Orbital Trauma.” Ohio Ophthalmological Society
Annual Meeting, Columbus, OH. January 2010.
Cebulla CM. “Spectral domain optical coherence tomography in a
murine retinal detachment and proliferative vitreoretinopathy model.” Katz SE. “Idiopathic Intracranial Hypertension: A Paradigm for Diagno-
Clinical Translational Science Meeting. Washington, DC. April 2010. sis and Management.” Department of Neurology, Ohio State University.
Columbus, Ohio. February 2010.
Cebulla CM. “Two case presentations in uveal melanoma.” First Annual
Wills Intraocular Tumor Symposium. Wills Eye Hospital. Philadelphia, Katz SE. “The Pupil.” Department of Neurology, Ohio State University.
PA. April 2010. Columbus, OH. April 2010.
Chang S. “Age Related Macular Degeneration.” OSU MedNet21. Katz SE. “Pulsatile Tinnitus, Hearing Loss and Spontaneous Cerebrospi-
Center for Continuing Medical Education. The Ohio State University nal Fluid Leaks in Idiopathic Intracranial Hypertension.” Department of
Medical Center. February 2009. Otolaryngology, The Ohio State University. Columbus, OH. May 2010.
Christoforidis JB. “The Effect of Intravitreal Pegaptanib, Bevacizumab Katz SE. “Diplopia.” Department of Neurology, Ohio State University.
and Ranibizumab on Blood Vessel Formation During Cutaneous Wound Columbus, OH. May 2010.
Healing In a Rabbit Model.” Pan-Hellenic Ophthalmology Congress.
Thessaloniki, Greece. May 2010. Zhang L, Xu J, Letson AD, Roberts CJ, Xu R. “Targeted delivery of mul-
tifunctional microbubbles for anti-VEGF therapy of age-related macular
Christoforidis JB. “The Use of 7T MRI with dedicated eye coil to Image
degeneration.” The Association for Research in Vision and Ophthalmol-
Retrobulbar Vascular Structures.” Pan-Hellenic Ophthalmology Con-
ogy 2010 Annual Meeting. Fort Lauderdale, FL. May 2010.
gress. Thessaloniki, Greece. May 2010.
Christoforidis JB. “Intravitreal Pegaptanib, Bevacizumab and Ranibi- Roberts CJ. “Misconceptions and Misinterpretations in Corneal Topog-
zumab suppress angiogenesis during Cutaneous Wound Healing in a raphy.” Corneal Topographic Analysis and Anterior Segment Imaging:
rabbit model.” Nantucket Retina Meeting. Nantucket, MA. July 2010. Pearls for your Clinical Practice. ASCRS Course. April 2010.
Davidorf FH. “Ocular Manifestations of Systemic Histoplasmosis.” Roberts CJ. “Biomechanics of the Cornea” Refractive Surgery Didactic
American Academy of Ophthalmology, Fluorescein Club. San Francisco, Course, Advanced Session, XXVII Congress of the ESCRS. Barcelona,
CA. October 2009. Spain. September 2009.
Davidorf FH. “Focus on Diabetic Retinopathy and Macular Edema from Roberts CJ. “Biomechanics of the Cornea,” Keynote Lecture, Session I
a Clinical Perspective.” 2010 Aging Eye Summit: Diabetic Eye Disease. – The Cornea. United Kingdom &Ireland Society of Cataract & Refrac-
Prevent Blindness Ohio. Columbus, OH. June 2010. tive Surgeons. Leeds, UK. October 2009.
Roberts CJ. “Biomechanics of the Cornea.” Refractive Surgery Didac- Abdel-Rahman MH, Pilarski R, Massengill JB, Craven MA, Sexton JL,
tic Course, Part 2. 14th ESCRS Winter Refractive Surgery Meeting, Davidorf FH. "Cancer Family History Characterization and Candidate
Budapest Hungary. February 2010. Gene Testing in an Unselected Cohort of 121 Patients With Uveal
Melanoma"
Roberts CJ. “Scheimpflug Imaging: Are two cameras better than
one?” Imaging Symposium. 14th ESCRS Winter Meeting. Budapest,
Hungary. February 2010. Verma V, Abdel-Rahman MH, Cebulla CM, Davidorf FH. "Metastasis
in Small Uveal Melanomas"
Roberts CJ. “Galilei Dual Scheimpflug: The Best of Both Worlds.”
Ziemer Refractive Symposium. EyeWorld Corporate Mornings, AS- Tang J, He1 X, Liu J. "Effect of Ocular Tissue Viscoelasticity on Intra-
CRS. Boston, MA. April 2010. ocular Pressure Elevation Under Injection at Different Rates"
Roberts CJ. “Biomechanics in Ophthalmology.” Tel Aviv Medical
Center Department of Ophthalmology. Tel Aviv, Israel. May 2010. Zhang L, Xu J, Xu R, Roberts CJ. "Targeted Delivery of Multifunc-
tional Microbubbles for Anti-VEGF Therapy of Neovascular Age-
Roberts CJ. “Corneal Biomechanics.” Israeli Cornea Club. Tiberias, Related Macular Degeneration"
Israel. May 2010.
Roberts CJ, Mahmoud AM, Small RH. "The Response of Ocular Pulse
Roberts CJ. “Dynamic Corneal Topography.” Israeli Cornea Club.
Amplitude (OPA) to an Increase in Intraocular Pressure (IOP) Generat-
Tiberias, Israel. May 2010.
ed by Changing Subject Position, in Order to Investigate Ocular Blood
Roberts CJ. “Misconceptions and Misinterpretations in Corneal To- Flow and Validate a Novel Electrical Analog Model"
pography.” Israeli Cornea Club. Tiberias, Israel. May 2010.
Qazi1 MA, Mahmoud AM, Kollbaum PS, Twa MD, Roberts CJ,
Roberts CJ. “Galilei: Dual Scheimpflug with integrated Placido.” Pepose JS. "Application of a Quantitative Method for Identifying Risk
Israeli Cornea Club. Tiberias, Israel. May 2010.
for Ectasia After LASIK in Normal, Suspect, and Ectatic Eyes"
POSTGRADUATE SYMPOSIUM Kim B, Roberts CJ, Grzybowski DM, Weber PA, Zhao Y. "Nanoen-
gineered Polymer Scaffold With Controllable Porosity Towards 3D in
Cebulla CM. "Tumor Imaging" vitro Trabecular Meshwork Model"
Lewis JR. "Dual vs. Single Scheimpflug Anterior Segment Imaging"
Thiagarajasubramanian AK, Lubow M, Schultz B, Grzybowski DM.
Mauger TF. "Corneal Confocal Imaging"
"Transcranial Orbitotomy for Ocular-Orbital Histopathology: The
Roberts CJ. "Misconceptions & Misinterpretations in Corneal Topog- FULL Autopsy Is Not Full Enough"
raphy"
Roberts CJ. "Effective Posterior Power: How Is It Used for Prediction Mahmoud AM, Roberts CJ. "The Influence of Altered Posterior Angle
of Incidence on Effective Posterior Power Calculation Before and After
of IOL Power?"
LASIK"
Roberts CJ. "Dynamic Corneal Topography"
Sawchyn AK. "Using HRT to Manage Glaucoma" Kuruvilla OC, Horne A, Qureshi Z, Weber PA, Kelley C, Mauger TF,
Weber PA. "OCT – Glaucoma Overview" Roberts CJ. "Comparison of Heidelberg Retinal Tomography Image
Weber PA. "How Glaucoma OCT Imaging Can Enhance Patient Care" Quality in Clear Lenses vs. Monofocal IOLs vs. Multifocal IOLs"
Ready, Aim, Refract! Whitehead G, Rogers DL, McGregor M, Serna A. "Utility of the Con-
Castellano D. “To Flap or Not to Flap” vergence Insufficiency Symptom Survey in a Tertiary Care Center"
Tandon A. “PresbyLASIK - Fad or the Future?”
Hendershot AJ, Mahmoud AM, Mauger TF. "Cataract Surgery Simula-
Extra! Extra! Technology Stamps out Glaucoma! tors in the Training of Ophthalmology Residents"
Fleming GP. “Fourier Domain OCT”
Azrak MI. “Corneal Biomechanics & Glaucoma”
Lewis JR, Mahmoud A, Roberts CJ. "Recentration to the Pupil Center
Provides Consistency of Central Anterior Curvature Calculation Under
New Concepts in Keratoplasty
Kuennen R. “Endothelial Keratoplasty” Conditions of Misalignment"
Mauger TF. “PK and Beyond”
Christoforidis JB, Ricketts R, Bean S, Pratt C, Pierce J, Wells MB,
Spots in Your Eyes La Perle K. "The Effect of Intravitreal Pegaptanib, Bevacizumab and
Cebulla CM. “Pigmented Lesions & Tumor Lookalikes” Ranibizumab on Blood Vessel Formation During Cutaneous Wound
Wells M. “Dots, Flecks, and Spots” Healing in a Rabbit Model"
31
MISSIONS WORLDWIDE EFFORTS
BUCKEYES AROUND
THE GLOBE
BRINGING HOPE TO PATIENTS FROM UGANDA...
33
THE OHIO STATE UNIVERSITY Nonprofit Org.
HAVENER EYE INSTITUTE U.S. Postage
915 Olentangy River Rd, Suite 5000 PAID
Columbus, Ohio 43212 Columbus, Ohio
www.eye.osu.edu Permit No. 711
Once again, this year’s list for Columbus, Ohio honored the
hard work and dedication of OSU’s Ophthalmology faculty.