You are on page 1of 37

Pre Lab Session: Diseases of the Respiratory System

Jennifer J. Mananes, MD
Resident Department of Pathology DLSUMC

Diseases of the respiratory system


Alteration in lung expansion (Atelectasis) slide 107 Diseases of vascular origin Chronic Passive Congestion 79 Hemorrhagic infarction 104 ARDS 190 Pulmonary infections Bronchopneumonia 70 Tuberculosis 72 Aspergillosis 185 Tumors Primary Moderately differentiated squamous cell carcinoma 300 Bronchogenic carcinoma, large cell undiffiferentiated 109 Bronchial carcinoid 213 Secondary Metastatic Choriocarcinoma, metastatic 165

Obstructive pulmonary disease (Bronchiectasis and Emphysema)

Alteration in lung expansion (Atelectasis)

Greek words ateles and ektasis, ~ incomplete expansion. Collapse/ compression of a previously inflated lung.

Alteration in lung expansion (Atelectasis) slide 107

Atelectasis
What x-ray finding differentiates obstructive from compressive atelectasis?

Chronic Passive Congestion

Chronic Passive Congestion

Brown induration

Chronic Passive Congestion

slide 79

Hemorrhagic infarction

slide 104

Hemorrhagic infarction

ARDS 190

ARDS

Bronchopneumonia slide 70

Bronchopneumonia

Guide question: On the basis of the microscopic pathology, explain the occurrence of rales in bronchopneumonia.

Miliary tuberculosis

Miliary tuberculosis (Slide no. 72)

Note the tubercles composed of epithelioid cells, Langhans giant cells, and lymphocytes Type of inflammation? Necrosis? Etiology?

Aspergillosis

Aspergillosis slide 185

Squamous cell carcinoma

Squamous cell carcinoma

slide 300

Squamous cell carcinoma

Squamous cell carcinoma

Undifferentiated large cell carcinoma (Slide 109)

Bronchial carcinoid (Slide no. 213)

Note the nests of tumor cells surrounded by delicate fibrocollagenized connective tissue stroma Cells are small and uniform in size with scanty cytoplasm/ uniform cytologic pattern What is the histogenesis of this tumor? What is carcinoid syndrome?

Metastatic choriocarcinoma (Slide 165)

Note the extensive hemorrhage

Choriocarcinoma, metastatic
Cytotrophoblast vs Syncytiotrophoblast Rounder with vesicular nuclei and prominent nucleoli Spindlly, irregularly-shaped, and hyperchromatic nuclei

Guide Question---Explain why the liver and the lungs are the two most frequently involved organs in hematogenous metastatic carcinoma.

Obstructive pulmonary disease : Emphysema

Obstructive pulmonary disease : Emphysema

Obstructive pulmonary disease:

Emphysema

Obstructive pulmonary disease:

Bronchiectasis

Bronchiectasis

You might also like