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Chapter 16 Lymphatic System and Immunity Understanding Words (p.616) Prefix AutoDefinition Self Example Autoimmune diseaseimmune system attacking the bodys tissue Humoral immunityimmunity resulting from antibodies in body fluids Immunity-resistance to (freedom from) a specific disease Inflammation: localized redness, heat, swelling, and pain in the tissues Nodule-small mass of lymphocytes surrounded by CTs Pathogen-disease causing agent
Humor-
Moisture, fluid
Immune-
Free, exempt
Inflamm-
To set on fire
Nod-
Knot
Patho-
Disease, sickness
Suffix -gen
Table 16.2 Major Actions of an Inflammation Response p.627 Action Blood vessels dilate. Capillary permeability increases and fluid leaks into tissue spaces WBCs invade the region Tissue fluids containing clotting factors seep into the area Fibroblasts arrive Phagocytes are active Cells divide Result Tissues become red, swollen, warm, painful Pus may form as WBCs, bacterial cells, and cellular debris accumulate A clot containing threads of fibrin may form CT sac may form around injured tissues Bacteria, dead cells, and other debris removed Newly formed cells replace injured ones
Chemical barriers
Table 16.4 A comparison of T cells and B cells p.630 Characteristic Origin of undifferentiated cell Site of differentiation Primary locations T cells Red bone marrow Thymus Lymphatic tissues, to%-80% of the circulating lymphocytes in blood Provide cellular immune response in which T cells interact directly with the antigens or antigen-bearing agents to destroy them B cells Red bone marrow Red bone marrow Lymphatic tissues, 20%-30% of the circulating lymphocytes in blood Provide humoral immune response in which B cells interact indirectly, producing antibodies that destroy the antigens or antigen-bearing agents
Primary functions
Table 16.7 Characteristics of major immunoglobulins p.635 Type IgG IgA IgM Major Function Defends against bacteria, viruses, and toxins; activates complement Defends against bacteria and viruses Reacts with antigens on some RBC membranes following mismatched blood transfusions; activates complement B cell activation Promotes inflammation and allergic reactions
IgD IgE
Table 16.8 Actions of antibodies p.636 Effect Agglutination Precipitation Neutralization Opsonization Chemotaxis Agglutination Lysis Description Antigens clump Antigens become insoluble Antigens lose toxic properties Alters antigen cell membranes so cells are more susceptible to phagocytosis Attracts macrophages and neutrophils into the region Clumping of antigen-bearing cells Allows for rapid movement of water and ions into the foreign cell causing osmotic rupture of the foreign cell Altering the molecular structure of viruses, making them harmless Helps prevent the spread of antigens
Neutralization Inflammation
Exposure to a vaccine containing weakened or dead pathogens or their components Injection of gamma globulin containing antibodies or antitoxin Antibodies passed to fetus from pregnant woman with active immunity or to newborn through breast milk from a woman with active immunity
Table 16.10 Transplant Types p.641 Type Isograft Donor Identical twin Example Bone marrow transplant from a healthy twin to a twin who has leukemia Skin graft from one part of the body to replace burned skin Kidney transplant from a relative or closely matched donor Heart valves from a pig
Table 16.11 Autoimmune Disorders p.642 Disorder Glomerulonephritis Symptoms Lower back pain Antibodies against Kidney cell antigens that resemble streptococcal bacteria antigens Thyroid gland antigen near TSH receptor, causing overactivity Pancreatic beta cells RBCs Myelin white matter of the CNS
Graves disease
Restlessness, weight loss, irritability, increased heart rate, and bp Thirst, hunger, weakness, emaciation Fatigue and weakness Weakness, incoordination, speech disturbances, visual complaints 4
Ulcerative colitis
Joint pain and deformity Red rash on face, prolonged fever, weakness, kidney damage, joint pain Lower abdominal pain
Colon cells
Clinical Application Table 16B how HIV is not transmitted p.643 Casual contact (social kissing, hugging, handshake) Objects (toilet seats, deodorants sticks, doorknobs) Mosquitoes Sneezing & coughing Sharing food Swimming in the same water Donating blood
Innerconnections p.645 Lymphatic system Important link between tissue fluid and the plasma; it also plays a major role in the response to infection Skin is a first line of defense against infection Lymphatic system returns tissue fluid to the bloodstream. Lymph originates as tissue fluid, formed by the action of blood pressure Cells of the immune system originate in the bone marrow Lymph plays a major role in the absorption of fats Muscle action helps pump lymph through the lymphatic vessels Cells of the immune system patrol the respiratory system to defend against infection Stress may impair the immune response The kidneys control the volume of extracellular fluid, including lymph Hormones stimulate lymphocyte production Special mechanisms inhibit the female immune system in its attack of sperm as foreign invaders 5
Skeletal system Digestive system Muscular system Respiratory system Nervous system Urinary system Endocrine system Reproductive system
DeciduFrenul-
Gastr-
Stomach
Hepat-
Liver
Hiat-
Opening
LinguPeri-
Tongue Around
Pyl-
Gatekeeper, door
RectSorptVill-
Alimentary Canal Mouth Pharynx Esophagus Small intestine Mechanical breakdown of food; begins chemical digestion of carbohydrates Connects mouth with esophagus Peristalsis pushes food to stomach Mixes food with bile pancreatic juice; final enzymatic breakdown of food molecules; main site of nutrient absorption Absorbs water and electrolytes to form feces Regulates elimination of feces
Table 17.1 layers of the wall of the alimentary canal Layer Mucosa Submucosa Muscular layer Serosa
p655 Function Protection, secretion, absorption Nourishes, surrounding tissues, transports absorbed materials Movements of the tube and its contents Protection, lubrication
Table 17.3 mouth parts and their function in digestion p660 Part Cheeks Lips Tongue Location Form lateral walls of mouth Surround mouth opening Floor of mouth Function Hold food in mouth; muscles chew food Contain sensory receptors used to judge characteristics of foods Mixes food with saliva; moves food toward pharynx; contains taste receptors Holds food in mouth; directs
Palate
Table 17.4 The major salivary glands p663 Gland Parotid glands Location Anterior to and somewhat inferior to the ears between the skin of the cheeks and the masseter muscles In the floor of the mouth on the inside surface of the mandible In the floor of the mouth inferior to the tongue Type of secretion Clear, watery serous fluid, rich in salivary amylase
Submandibular glands
Sublingual glands
Some serous fluid with some mucus; more viscous than parotid secretion Primarily thick, stringy mucus
Table 17.5 major components of gastric juice p668 Component Pepsinogen Pepsin Source Chief cells of gastric glands Formed from pepsinogen in the presence of hydrochloric acid Parietal cells of the gastric glands Function Inactive form of pepsin A protein-splitting enzyme that digests nearly all types of dietary protein Provides the acidic environment needed for production and action of pepsin Provides a viscous, alkaline protective layer on the stomachs inner surface Aids in vitamin B12 absorption
Hydrochloric acid
Mucus
Mucous cells
Intrinsic factor
Table 17.6 phases of gastric secretion p669 Phase Cephalic phase Action The sight, taste, smell, or thought of food triggers parasympathetic reflexes. Gastric juice is secreted in response Food in stomach chemically and mechanically stimulates secretion of gastrin, which in turn, stimulates secretion of gastric juice; reflex responses also stimulate gastric juice secretion As food enters the small intestine, it stimulates 8
Gastric phase
Intestinal phase
Table 17.7 major functions of the liver p677 Carbohydrate metabolism Lipid metabolism Protein metabolism Storage Blood filtering Detoxification Secretion
Table 17.8 hormones of the digestive tract p678 Hormone Gastrin Intestinal gastrin Somatostatin Intestinal somatostatin cholecytoskinin Secretin source Gastric cells, in response to food Cells of small intestine, in response to chyme Gastric cells Intestinal wall cells, in response to fats Intestinal wall cells, in response to proteins and fats in the small intestine Cells in the duodenal wall, in response to acidic chyme entering the small intestine
Table 17.9 summary of the major digestive enzymes p683 Enzyme Salivary amylase Gastric enzymes Pepsin Gastric lipase Pancreatic enzymes Pancreatic amylase Pancreatic lipase Trypsin, chymotrypsin Carboxypeptidase Nucleases Intestinal enzymes Peptidase 9 Digestive action Begins carbohydrate digestion by breaking down starch and glycogen to disaccharides Begins protein digestion Begins butterfat digestion Breaks down starch and glycogen into disaccharides Breaks down fats into fatty acids and glycerol Breaks down proteins or partially digested proteins in to peptides Breaks down peptides into amino acids Breaks down nucleic acids into nucleotides Breaks down peptides into amino acids
Table 17A Diagnostic tests for colorectal cancer p691 Diagnostic test Digital rectal exam Double-contrast barium enema Fecal occult blood test Colorectal cancer gene test (experimental) Sigmoidoscopy Colonoscopy Description Physician palpates large intestine and rectum x-ray exam following ingestion of contrast agent highlights blockages in large intestine Blood detected in feces sample Mutations associated with colorectal cancer detected in DNA of cells shed with feces Endoscopic views rectum and lower colon Endoscope views rectum and entire colon
Innerconnections p692 Digestive system Integumentary system Skeletal system Muscular system Ingests, digests, and absorbs nutrients for use by al body cells Vitamin D activated in the skin plays a role in absorption of calcium from the digestive tract Bones are important in mastication. Calcium absorption is necessary to maintain bone matrix Muscle are important in mastication, swallowing, and the mixing and moving of digestion products though the gastrointestinal tract Can influence digestive system activity Hormones can influence digestive system activity Bloodstream carries absorbed nutrients to all body cells Plays a major role in the absorption of fats D.S. and R.S. share common anatomical structures Kidneys and liver work together to activate vitamin D In a woman, nutrition is essential for conception and normal development of an embryo and fetus
Nervous system Endocrine system Cardiovascular system Lymphatic system Respiratory system Urinary system Reproductive system
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CalorCarot-
Heat Carrot
LipMal-
NutriObesPell-
Suffix -meter
Definition Measure
Table 18.1 types of vegetarian diets p699 Type Vegan Ovo-vegetarian Lacto-vegetarian Lacto-ovo-vegetarian Pesco-vegetarian Semivegetarian Food restrictions No animal foods Eggs allowed; no dairy or meat Dairy allowed; no eggs or meat Dairy and eggs allowed; no meat Dairy, eggs and fish allowed; no other meat Dairy, eggs, chicken and fish allowed; no other meat
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Leptin
Adipocytes
Neuropeptide Y Ghrelin
Hypothalamus Stomach
Table 18.4 carbohydrate, lipid, and protein nutrients Nutrient Carbohydrate Calories per gram 4.1 Conditions associated with Excess Deficiencies Obesity, Metabolic acidosis dental caries, nutritional deficits Obesity, Weight loss, skin increased lesions serum cholesterol, increased risk of heart disease Obesity Extreme weight loss, wasting, anemia, growth retardation
Lipid
9.5
Proteins
4.1
Table 18.6 Vitamin Fallacies and Facts Fallacy The more vitamins, the better Fact Too much of a water-soluble vitamin results in excretion of the vitamin through urination; too much of a fat-soluble vitamin can harm health Many people do need vitamin supplements, particularly pregnant and breast-feeding women Vitamins do not directly supply energy; they air in release of energy from carbohydrates, fats, and proteins 12
Vitamin A
Vitamin D
Vitamin E
Vitamin K
An antioxidant necessary for synthesis of visual pigment, mucoproteins, & mucopolysaccharides; for normal development of bones and teeth; maintenance of epithelial cells Promotes absorption of calcium and phosphorus; promotes development of teeth and bones An antioxidant; prevents oxidation of vitamin A and polyunsaturated fatty acids; may help maintain stability of cell membranes Required for synthesis of prothrombin, which functions in blood clotting
Produced in skin exposed to UV light; in milk, egg yolk, fish liver oils, fortified foods 400IU Oils from cereal seeds, salad, oils, margarine, shortenings, fruits, nuts, vegetables 30IU Leafy green vegetables, egg yolk, pork liver, soy oil, tomatoes, cauliflower
Table 18.9 Water-soluble vitamins p719 Vitamin Functions Sources for RDA for adults Len meats, liver, eggs, whole-grain cereals, leafy green vegetables, legumes 1.5 mg 13 Conditions associated with Excess Uncommon, vasodilation, cardiac dysrhythmias Deficiencies Beriberi, muscular weakness, enlarged heart
Part of coenzyme required for oxidation of carbohydrates; coenzyme required for ribose synthesis
Vitamin B6
Meats, whole grain cereals, legumes, milk, fruits, vegetables 10mg Liver, meats, bananas, beans, peanuts, wholegrain cereals, egg yolk 2mg
None known
Rare, loss of appetite, mental depression, muscle spasms Rare, convulsions, vomiting seborrhea lesions
None known
Pernicious anemia
None known
Megaloblastic anemia
Biotin
None known
Table 18.10 major minerals Mineral Functions Sources and RDA for adults Milk, milk products, leafy green vegetables 800mg Conditions associated with Excess Kidney stones, deposition of calcium phosphate in soft tissues None known Deficiencies Stunted growth, misshapen bones, fragile bones, tetany Stunted growth
Calcium/ Ca
Structure of bones and teeth; essential for neurotransmitter release, muscle fiber contraction, and blood
Phosphorus (P)
Potassium
Structure of bones and teeth; in nearly all metabolic reactions; in nucleic acids, many proteins, some enzymes, and some vitamins; in cell membrane, ATP, and phosphates of body fluids Helps maintain intracellular
Avocados, dried 15
Uncommon
Muscular
Sulfur (S)
Essential part of certain amino acids, thiamine, insulin, biotin, and mucopolysaccharides Sodium (Na) Helps maintain osmotic pressure of extracellular fluids; regulates water movement; plays a role in nerve impulse conduction; regulates pH and transport of substances across cell membranes Chloring (Cl) Helps maintain osmotic pressure of extracellular fluids, regulates pH, maintains electrolyte balance; forms hydrochloric acid; aids transport of carbon dioxide by RBCs Magnesium Required in metabolic reactions (Mg) in mitochondria that produce ATP; plays a role in the breakdown of ATP to ADP
None known
Vomiting
Cramps
Diarrhea
Neuromascular disturbances
Table 18.11 trace elements p723 Trace element Functions Sources & RDA for adults Liver, lean meats, dried apricots, raisins, enriched whole-grain cereals, legumes, molasses 10-18mg Nuts, legumes, wholegrain cereals, leafy green vegetables, fruits 2.5-5 mg Conditions associated with Excess Liver damage Deficiencies Anemia
Iron (Fe)
Part of hemoglobin molecule; catalyzes formation of vitamin A; incorporated into a number of enzyme Activates enzymes required for fatty acids and cholesterol synthesis, formation of urea, and normal functioning of the nervous system Essential for hemoglobin
Manganese (Mn)
None known
None known
Copper (Cu)
Rare
Rare
Iodine (I)
Cobalt (Co)
Zinc (ZN)
Component of cyanocobalamin; required for synthesis several enzymes Component of enzymes involved in digestion, respiration, bone metabolism, liver metabolism; necessary for normal wound healing and maintaining integrity of the skin Component of tooth structure Components of certain enzymes Essential for use of carbohydrates
Food content varies with soul content in different geographic regions; iodized table salt 0.15mg Liver, lean meats, milk No RDA established
Heart disease
Fluoridated water (1.5-4mg) Lean meats, fish, cereals 0.05-2mg Liver, lean meats, wine 0.05-2mg
Figure 18.20 food guide pyramids-difference between the pyramids p722 Food pyramids organize foods according to suggested proportions of the diet, often in serving sizes. One food pyramid, developed in the US Dept of Agriculture, dominated for years, but new ones offer more specific suggestions geared to age, health, ethnicity, food preferences such as vegetarianism or weight loss goals. Past pyramids can seem strange in light of todays individualized goals. A plan from the 1940s had 8 categories, including separate groups for butter and margarine, and for eggsfoods now associated with the development of heart disease. In the 1920s, an entire food group was devoted to swets.
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