LISTE DES MDICAMENTS ESSENTIELS GNRIQUES PUBLIE PAR L'OMS

1. ANAESTHETICS 1.1 General anaesthetics and oxygen ether, anaesthetic halothane ketamine hydrochloride nitrous oxide oxygen *thiopental sodium 1.2 Local anaesthetics *bupivacaine hydrochloride (2) inhalation (medicinal gas). powder for injection, 0.5 g, 1.0 g in ampoule. injection, 0.25%, 0.5% in vial; injection for spinal anaesthesia, 0.5% in 4-ml ampoule to be mixed with 7.5% glucose solution. injection, 1%, 2% in vial; injection for spinal anaesthesia, 5% in 2-ml ampoule to be mixed with 7.5% glucose solution; topical forms, 2-4%. injection 1%, 2% + epinephrine 1:200 000 in vial; dental cartridge 2% + epinephrine 1:80 000.

(1c, 2) (2) (2) (2)

inhalation. inhalation. injection, 50 mg/ml in 10-ml vial. inhalation.

(2, 9)

*lidocaine hydrochloride *lidocaine hydrochloride + epinephrine

Complementary drug(s) ephedrine hydrochloride* (C) injection, 30 mg/ml in 1-ml ampoule. *To prevent hypotension in spinal anaesthesia during delivery. 1.3 Preoperative medication and sedation for short-term procedures atropine sulfate injection, 1 mg in 1-ml ampoule. chloral hydrate syrup, 200 mg/5 ml. *diazepam (1b) injection, 5 mg/ml in 2-ml ampoule; tablet, 5 mg. *morphine hydrochloride (1a) injection, 10 mg in 1-ml ampoule. *morphine sulfate (1a) injection, 10 mg in 1-ml ampoule. *promethazine hydrochloride elixir or syrup, 5 mg/5 ml. 2. ANALGESICS, ANTIPYRETICS, NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, DRUGS USED TO TREAT GOUT AND DISEASE MODIFYING ANTI-RHEUMATOID DRUGS (DMARDs) 2.1 Non-opioids and NSAIDs acetylsalicylic acid *ibuprofen paracetamol 2.2 Opioid analgesics *codeine phosphate *morphine hydrochloride *morphine sulfate *pethidine hydrochloride (1a) (1a) (1a) (A) (1a, 4)

tablet, 100-500 mg; suppository, 50-150 mg. tablet, 200 mg, 400 mg. tablet, 100-500 mg; suppository, 100 mg; syrup, 125 mg/5 ml. tablet, 30 mg. injection, 10 mg in 1-ml ampoule; oral solution, 10 mg/5 ml.. injection, 10 mg in 1-ml ampoule; oral solution, 10 mg/5 ml; tablet, 10 mg. injection, 50 mg in 1-ml ampoule; tablet, 50 mg, 100 mg.

2.3 Drugs used to treat gout allopurinol (4) tablet, 100 mg. colchicine (7) tablet, 500 micrograms. 2.4 Disease modifying anti-rheumatoid drugs (DMARDs) azathioprine (2) tablet, 50 mg.

chloroquine phosphate (2) tablet, 100 mg, 150 mg of chloroquine. chloroquine sulfate (2) tablet, 100 mg, 150 mg of chloroquine. cyclophosphamide (2) tablet, 25 mg. methotrexate sodium (2) tablet, 2.5 mg. penicillamine (2) capsule or tablet, 250 mg. sulfasalazine (2) tablet, 500 mg. 3. ANTIALLERGICS AND DRUGS USED IN ANAPHYLAXIS *chlorphenamine hydrogen maleate tablet, 4 mg; injection, 10 mg in 1-ml ampoule. *dexamethasone *dexamethasone disodium phosphate epinephrine hydrogen tartrate epinephrine hydrochloride tablet, 500 micrograms, 4 mg. injection, 4 mg of dexamethasone phosphate in 1-ml ampoule. injection, 1 mg of epinephrine in 1-ml ampoule.

injection, 1 mg of epinephrine in 1-ml ampoule. powder for injection, 100 mg of hydrocortisone in hydrocortisone sodium succinate vial. *prednisolone tablet, 5 mg. 4. ANTIDOTES AND OTHER SUBSTANCES USED IN POISONING 4.1 Non-specific *charcoal, activated ipecacuanha 4.2 Specific atropine sulfate calcium gluconate deferoxamine mesilate dimercaprol *methionine (DL-) methylthioninium chloride (methylene blue) naloxone hydrochloride penicillamine potassium ferric hexacyano-ferrate(II) (Prussian blue) sodium calcium edetate sodium nitrite (2)

powder. syrup, containing 0.14% ipecacuanha alkaloids calculated as emetine. injection, 1 mg in 1-ml ampoule. injection, 100 mg in 10-ml ampoule. powder for injection, 500 mg in vial. injection in oil, 50 mg/ml in 2-ml ampoule. tablet, 250 mg. injection, 10 mg/ml in 10-ml ampoule. injection, 400 micrograms in 1-ml ampoule. capsule or tablet, 250 mg. powder for oral administration. (2) injection, 200 mg/ml in 5-ml ampoule. injection, 30 mg/ml in 10-ml ampoule. injection, 250 mg/ml in 50-ml ampoule. scored tablet, 100 mg, 200 mg. injection, 5 mg/ml in 2-ml ampoule (intravenous or rectal). capsule, 250 mg; syrup, 250 mg/5 ml. tablet, 15-100 mg; elixir, 15 mg/5 ml. capsule or tablet, 25 mg, 50 mg, 100 mg; injection, 50 mg/ml in 5-ml vial. enteric coated tablet, 200 mg, 500 mg. scored tablets 500 micrograms. injection, 500 mg/ml in 2-ml ampoule; injecton, 5 g/10 ml in ampoule.

(2, 8) (2)

sodium thiosulfate 5. ANTICONVULSANTS/ANTIEPILEPTICS carbamazepine (10,11) *diazepam ethosuximide phenobarbital phenytoin sodium sodium valproate Complementary drug(s) *clonazepam magnesium sulfate 6. ANTI-INFECTIVE DRUGS 6.1 Anthelminthics 6.1.1 Intestinal anthelminthics albendazole (1b) (1b, 11) (7, 11) (7, 11) (B) (1b) (C)

chewable tablet, 400 mg.

levamisole hydrochloride *mebendazole niclosamide praziquantel pyrantel embonate 6.1.2 Antifilarials diethylcarbamazine dihydrogen citrate ivermectin Complementary drug(s) suramin sodium (B) (2, 7) 6.1.3 Antischistosomals and anti-trematode drugs praziquantel triclabendazole Complementary drug(s) oxamniquine 6.2 Antibacterials 6.2.1 Beta lactam drugs *amoxicillin (anhydrous) ampicillin sodium benzathine benzylpenicillin benzylpenicillin potassium benzylpenicillin sodium *cloxacillin sodium (4)

tablet, 50 mg of levamisole, 150 mg of levamisole. chewable tablet, 100 mg, 500 mg. chewable tablet, 500 mg. tablet, 150 mg, 600 mg. chewable tablet 250 mg of pyrantel; oral suspension, 50 mg of pyrantel/ml. tablet, 50 mg, 100 mg. scored tablet, 3 mg, 6 mg. powder for injection, 1 g in vial. tablet, 600 mg. tablet, 250 mg. (C) (8) capsule, 250 mg; syrup, 250 mg/5 ml.

phenoxymethylpenicillin potassium procaine benzylpenicillin Reserve antibacterials *amoxicillin + *clavulanic acid ceftazidime pentahydrate *ceftriaxone sodium imipenem + cilastatin sodium 6.2.2 Other antibacterials *chloramphenicol *chloramphenicol palmitate *chloramphenicol sodium succinate *ciprofloxacin hydrochloride *doxycycline hyclate *erythromycin ethylsuccinate *erythromycin lactobionate *erythromycin stearate *gentamicin sulfate (2, 4, 7, 11) (D) (D) (D) (D) (7) (7) (7) (5, 6)

capsule or tablet, 250 mg, 500 mg; powder for oral suspension, 125 mg/5 ml. powder for injection, 500 mg, 1 g, in vial. powder for injection, 1.44 g of benzylpenicillin (=2.4 million IU) in 5-ml vial. powder for injection, 600 mg (= 1 million IU), 3 g (= 5 million IU) in vial. powder for injection, 600 mg (= 1 million IU), 3 g (= 5 million IU) in vial. capsule, 500 mg, 1 g of cloxacillin; powder for oral solution, 125 mg of cloxacillin/5 ml; powder for injection, 500 mg of cloxacillin in vial. tablet, 250 mg of phenoxymethylpenicillin; powder for oral suspension, 250 mg of phenoxymethylpenicillin/5 ml. powder for injection, 1 g (=1 million IU), 3 g (=3 million IU). tablet, 500 mg + 125 mg. powder for injection, 250 mg of ceftazidime in vial. powder for injection, 250 mg of ceftriaxone in vial. powder for injection 250 mg + 250 mg, 500 mg + 500 mg in vial. capsule, 250 mg. oral suspension, 150 mg of chloramphenicol/5 ml. powder for injection, 1 g of chloramphenicol in vial. tablet 250 of ciprofloxacin. capsule or tablet, 100 mg of doxycycline. capsule or tablet, 250 mg of erythromycin; powder for oral suspension, 125 mg of erythromycin.. powder for injection, 500 mg of erythromycin in vial. capsule or tablet, 250 mg of erythromycin; powder for oral suspension, 125 mg of erythromycin. injection, 10 mg, 40 mg of gentamicin/ml in 2-ml vial.

*metronidazole *metronidazole benzoate nalidixic acid nitrofurantoin spectinomycin hydrochloride *sulfadiazine *sulfadiazine sodium *sulfamethoxazole + trimethoprim trimethoprim Complementary drug(s) chloramphenicol sodium succinate clindamycin clindamycin phosphate Reserve antibacterial vancomycin hydrochloride 6.2.3 Antileprosy drugs clofazimine dapsone rifampicin 6.2.4 Antituberculosis drugs ethambutol hydrochloride isoniazid isoniazid + ethambutol hydrochloride pyrazinamide rifampicin rifampicin + isoniazid* *For intermittent use three times weekly. rifampicin + isoniazid + pyrazinamide* *For intermittent use three times weekly. streptomycin sulfate Complementary drug(s) thioacetazone + isoniazid 6.3 Antifungal drugs amphotericin B griseofulvin *ketoconazole nystatin Complementary drug(s) flucytosine potassium iodide 6.4 Antivirals 6.4.1 Antiherpes aciclovir aciclovir sodium 6.4.2 Antiretrovirals zidovudine (B) (4, 8) (A) (5) (4) (A) (5, 7) (4) (8) (2) (5) (C) (B) (8) (B) (8) (D) (8) (4, 8) (8) (4) (4) (4) (8)

tablet, 200-500 mg; injection, 500 mg in 100-ml vial; suppository, 500 mg, 1 g. oral suspension, 200 mg of metronidazole/5 ml. tablet 250 mg, 500 mg. tablet, 100 mg. powder for injection, 2 g of spectinomycin in vial. tablet, 500 mg. injection, 250 mg in 4-ml ampoule. tablet, 100 mg + 20 mg, 400 mg + 80 mg; oral suspension, 200 mg + 40 mg/5 ml; injection, 80 mg + 16 mg/ml in 5-ml and 10-ml ampoules. tablet, 100 mg, 200 mg; injection 20 mg/ml in 5-ml ampoule. oily suspension for injection 0.5 g of chloramphenicol/ml in 2-ml ampoule. capsule, 150 mg. injection, 150 mg of clindamycin. powder for injection, 250 mg of vancomycin in vial. capsule, 50 mg, 100 mg. tablet, 25 mg, 50 mg, 100 mg. capsule or tablet, 150 mg, 300 mg.

(4) (5)

tablet, 100 mg-400 mg. tablet, 100 - 300 mg. tablet, 150 mg + 400 mg. tablet, 400 mg. capsule or tablet, 150 mg, 300 mg. tablet, 150 mg + 75 mg; 300 mg + 150 mg; 150 mg + 150 mg. tablet, 150 mg + 75 mg + 400 mg; 150 mg + 150 mg + 500 mg. powder for injection, 1 g of streptomycin in vial. tablet, 50 mg + 100 mg; 150 mg + 300 mg. powder for injection, 50 mg in vial. capsule or tablet, 125 mg, 250 mg. tablet, 200 mg; oral suspension, 100 mg/5 ml. tablet, 100,000, 500,000 IU; lozenge 100,000 IU; pessary, 100,000 IU. capsule, 250 mg; infusion, 2.5 g in 250 ml. saturated solution.

(8) (8) (8)

tablet, 200 mg. powder for injection, 250 mg of aciclovir. capsules 100 mg, 250 mg; injection, 10 mg/ml in 20ml vial; oral solution 50 mg/5-ml.

Drugs for treatment of HIV/AIDS include Nucleoside Reverse Transcriptase Inhibitors (NRTIs), Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) and protease inhibitors (PIs). The prototype drug, zidovudine, has been shown to reduce or prevent mother-to-child transmission. THIS IS THE ONLY INDICATION FOR WHICH IT IS INCLUDED HERE. Single drug use with zidovudine, except in pregnancy, is now regarded as obsolete, because of the development of resistance. Triple therapy is beyond the budgets of most national drug programmes and therefore HIV/AIDS treatment policies must be decided at country or institutional level. 6.5 Antiprotozoal drugs 6.5.1 Antiamoebic and antigiardiasis drugs *diloxanide furoate *metronidazole *metronidazole benzoate 6.5.2 Antileishmaniasis drugs *meglumine antimonate pentamidine isetionate Complementary drug(s) amphotericin B 6.5.3 Antimalarial drugs 6.5.3.1 For curative treatment *chloroquine hydrochloride *chloroquine phosphate (5) (B) (4)

tablet, 500 mg. tablet, 200-500 mg; injection, 500 mg in 100-ml vial. oral suspension 200 mg of metronidazole/5 ml. injection, 30%, equivalent to approximately 8.5% antimony, in 5-ml ampoule. powder for injection, 200 mg, 300 mg in vial. powder for injection, 50 mg in vial.

*chloroquine sulfate primaquine diphosphate *quinine bisulfate *quinine dihydrochloride *quinine sulfate Complementary drug(s) *doxycycline hyclate* (B) *For use only in combination with chloroquine. mefloquine hydrochloride (B) *sulfadoxine + pyrimethamine (B) Reserve antimalarial artemether (D) 6.5.3.2 For prophylaxis chloroquine phosphate chloroquine sulfate mefloquine hydrochloride proguanil hydrochloride* *For use only in combination with chloroquine. 6.5.4 Anti-pneumocystosis and anti-toxoplasmosis drugs pentamidine isetionate (2) pyrimethamine sulfamethoxazole + trimethoprim 6.5.5. Antitrypanosomal drugs 6.5.5.1 African trypanosomiasis melarsoprol pentamidine isetionate

injection 40 mg of chloroquine/ml in 5-ml ampoule. tablet 100 mg, 150 mg of chloroquine; syrup, 50 mg of chloroquine/5 ml; injection 40 mg of chloroquine/ml in 5-ml ampoule. tablet 100 mg, 150 mg of chloroquine; syrup, 50 mg of chloroquine/5 ml; injection 40 mg of chloroquine/ml in 5 ml ampoule. tablet, 7.5 mg, 15 mg of primaquine. tablet, 300 mg. injection, 300 mg/ml in 2-ml ampoule. tablet, 300 mg. capsule or tablet, 100 mg. tablet, 250 mg of mefloquine. tablet, 500 mg + 25 mg. injection, 80 mg/ml in 1-ml ampoule. tablet, 150 mg of chloroquine; syrup, 50 mg of chloroquine/5 ml. tablet, 150 mg of chloroquine; syrup, 50 mg of chloroquine/5 ml. tablet, 250 mg of mefloquine. tablet, 100 mg.

tablet 200 mg, 300 mg. tablet, 25 mg. injection 80 mg + 16 mg in 5 ml ampoule.

(5) (5)

injection, 3.6% solution. powder for injection, 200 mg, 300 mg in vial.

suramin sodium Complementary drug(s) eflornithine hydrochloride 6.5.5.2 American trypanosomiasis benznidazole nifurtimox 6.6 Insect repellents diethyltoluamide 7. ANTIMIGRAINE DRUGS

(5) (C) (7) (2, 8)

powder for injection, 1 g in vial. injection, 200 mg/ml in 100-ml bottles. tablet, 100 mg. tablet, 30 mg; 120 mg; 250 mg. topical solution, 50%, 75%.

7.1 For treatment of acute attack acetylsalicylic acid tablet, 300 - 500 mg. ergotamine tartrate (7) tablet, 1 mg. paracetamol tablet, 300-500 mg. 7.2 For prophylaxis *propranolol hydrochloride tablet, 20 mg, 40 mg. 8. ANTINEOPLASTIC AND IMMUNOSUPPRESSIVES DRUGS 8.1 Immunosuppressive drugs *azathioprine *azathioprine sodium ciclosporin* *For organ transplantation. 8.2 Cytotoxic drugs asparaginase bleomycin sulfate calcium folinate chlormethine hydrochloride cisplatin cyclophosphamide cytarabine dacarbazine dactinomycin *doxorubicin hydrochloride etoposide fluorouracil levamisole hydrochloride mercaptopurine methotrexate sodium procarbazine hydrochloride vinblastine sulfate vincristine sulfate 8.3 Hormones and antihormones *prednisolone *prednisolone sodium phosphate *prednisolone sodium succinate tamoxifen citrate 9. ANTIPARKINSONISM DRUGS *biperiden hydrochloride *biperiden lactate levodopa + *carbidopa (5, 6)

(2) (2) (2)

tablet, 50 mg. powder for injection, 100 mg of azathioprine in vial. capsule, 25 mg; concentrate for injection 50 mg/ml in 1-ml ampoule.

(2) (2) (2) (2) (2) (2) (2) (2) (2) (2) (2) (2) (2) (2) (2) (2) (2)

powder for injection, 10,000 IU in vial. powder for injection, 15 mg of bleomycin in vial. tablet, 15 mg; injection, 3 mg/ml in 10-ml ampoule. powder for injection, 10 mg in vial. powder for injection, 10 mg, 50 mg in vial. tablet, 25 mg; powder for injection, 500 mg in vial. powder for injection, 100 mg in vial. powder for injection, 100 mg in vial. powder for injection, 500 micrograms in vial. powder for injection, 10 mg, 50 mg in vial. capsule, 100 mg; injection, 20 mg/ml in 5-ml ampoule. injection, 50 mg/ml in 5-ml ampoule. tablet, 50 mg of levamisole. tablet, 50 mg. tablet, 2.5 mg of methotrexate; powder for injection, 50 mg of methotrexate in vial. capsule, 50 mg of procarbazine. powder for injection, 10 mg in vial. powder for injection, 1 mg, 5 mg in vial. tablet, 5 mg. powder for injection, 20 mg of prednisolone in vial, 25 mg of prednisolone in vial. powder for injection, 20 mg of prednisolone in vial, 25 mg of prednisolone in vial. tablet, 10 mg, 20 mg of tamoxifen. tablet, 2 mg. injection, 5 mg in 1-ml ampoule. tablet, 100 mg + 10 mg; 250 mg + 25 mg.

10. DRUGS AFFECTING THE BLOOD 10.1 Anti-anaemia drugs ferrous sulfate ferrous sulfate + sodium folate* *Nutritional supplement for use during pregnancy. hydroxocobalamin (2) sodium folate (2) Complementary drug(s) *iron dextran 10.2 Drugs affecting coagulation desmopressin acetate heparin sodium phytomenadione (8) injection, 4 micrograms/ml in 1-ml ampoule; nasal spray 10 micrograms/metered dose. injection, 1000 IU/ml, 5000 IU/ml, 20,000 IU/ml in 1-ml ampoule. injection, 10 mg/ml in 5-ml ampoule; tablet, 10 mg. (B) (5)

tablet, 60 mg Fe; oral solution, 25 mg Fe/1 ml. tablet equivalent to 60 mg iron + 400 micrograms sodium folate. injection, 1 mg in 1-ml ampoule. injection, 1 mg of folic acid in 1-ml ampoule. injection, equivalent to 50 mg Fe (as complex of iron (III) hydroxide with dextran)/ml in 2-ml ampoule.

protamine sulfate injection, 10 mg/ml in 5-ml ampoule. *warfarin sodium (2, 6) tablet, 1 mg, 2 mg and 5 mg. 11. BLOOD PRODUCTS AND PLASMA SUBSTITUTES 11.1 Plasma substitutes *dextran 70

injectable solution, 6%.

*polygeline injectable solution, 3.5%. 11.2 Plasma fractions for specific use All plasma fractions should comply with the WHO Requirements for the Collection, Processing and Quality Control of Blood, Blood Components, and Plasma Derivatives (Revised 1992). WHO Technical Report Series, No. 840, 1994, Annex 2. albumin, human (2, 8) injectable solution, 5%, 25%. Complementary drug(s) *factor VIII concentrate (C) (2, 8) (dried). *factor IX complex concentrate (coagulation (C) (2, 8) (dried). factors, II, VII, IX, X) 12. CARDIOVASCULAR DRUGS 12.1 Antianginal drugs *atenolol glyceryl trinitrate *isosorbide dinitrate *verapamil hydrochloride 12.2 Antiarrhythmic drugs *atenolol digoxin lidocaine hydrochloride verapamil hydrochloride Complementary drug(s) epinephrine hydrochloride isoprenaline hydrochloride *procainamide hydrochloride *quinidine sulfate 12.3 Antihypertensive drugs (8, 10) (C) (C) (B) (A) (7) (10)

tablet, 50 mg, 100 mg. tablet (sublingual), 500 micrograms. tablet (sublingual), 5 mg. tablet, 40 mg, 80 mg. tablet, 50 mg, 100 mg. tablet, 62.5 micrograms, 250 micrograms; oral solution 50 micrograms; injection 250 micrograms/ml in 2-ml ampoule.. injection, 20 mg/ml in 5-ml ampoule. tablet, 40 mg, 80 mg; injection, 2.5 mg/ml in 2-ml ampoule. injection 1 mg of epinephrine in 1-ml ampoule. injection, 20 micrograms/ml. tablet, 250 mg, 500 mg; injection, 100 mg/ml in 10ml ampoule. tablet, 200 mg.

(4, 11)

*atenolol *captopril *hydralazine hydrochloride *hydrochlorothiazide methyldopa *nifedipine *reserpine Complementary drug(s) *doxazosin mesilate *sodium nitroprusside 12.4 Drugs used in heart failure *captopril *digoxin (B) (C) (2, 8) (4, 11) (4, 11) (7) (10)

tablet, 50 mg, 100 mg. scored tablet, 25 mg. tablet, 25 mg, 50 mg; powder for injection, 20 mg in ampoule. scored tablet, 25 mg. tablet, 250 mg. sustained release formulations; tablet 10 mg. tablet, 100 micrograms, 250 micrograms; injection, 1 mg in 1-ml ampoule. tablet, 1 mg, 2 mg, 4 mg. powder for infusion, 50 mg in ampoule. scored tablet, 25 mg. tablet, 62.5 micrograms, 250 micrograms; oral solution, 50 micrograms/ml; injection, 250 micrograms/ml in 2-ml ampoule. tablet, 25 mg, 50 mg.

*hydrochlorothiazide 12.5 Antithrombotic drugs acetylsalicylic acid tablet, 100 mg. Complementary drug(s) streptokinase (C) powder for injection, 100,000 IU, 750,000 IU in vial. 12.6 Lipid-lowering agents lipid-lowering agents* *The Committee recognizes the value of lipid-lowering drugs in treating patients with hyperlipidaemia. However, there are many other risk factors for atherosclerosis and its complications including tobacco smoking and inadequately controlled hypertension. Most hyperlipidaemias can be controlled by diet. HMG-CoA reductase inhibitors, often referred to as "statins" are a family of potent and effective lipid-lowering drugs with a good tolerability profile. Several of them have now been shown to reduce fatal and non-fatal myocardial infarction, stroke, the need for coronary by-pass surgery and all-cause mortality. 13. DERMATOLOGICAL DRUGS (topical) 13.1 Antifungal drugs benzoic acid + salicylic acid *miconazole nitrate sodium thiosulfate Complementary drug(s) selenium sulfide 13.2 Anti-infective drugs *methylrosanilinium chloride (gentian violet) neomycin sulfate + *bacitracin zinc *potassium permanganate sulfadiazine silver 13.3 Anti-inflammatory and antipruritic drugs *betamethasone valerate (3) *calamine

ointment or cream, 6% + 3%. ointment or cream, 2%. solution, 15%. (C) detergent-based suspension, 2%. aqueous solution, 0.5%; tincture, 0.5%. ointment, 5 mg + 500 IU. aqueous solution 1:10 000. cream, 1%, in 500-g container. ointment or cream, 0.1% of betamethasone. lotion.

*hydrocortisone acetate ointment or cream, 1%. 13.4 Astringent drugs aluminium diacetate solution, 13% for dilution. 13.5 Drugs affecting skin differentiation and proliferation benzoyl peroxide lotion or cream, 5%. coal tar dithranol solution, 5%. ointment, 0.1%-2%.

fluorouracil *podophyllum resin salicylic acid urea 13.6 Scabicides and pediculicides *benzyl benzoate

(7)

ointment, 5%. solution, 10-25%. solution (topical) 5%. ointment or cream, 10%. lotion, 25%. cream 5%; lotion 1%.

permethrin 13.7 Ultraviolet blocking agents Complementary drugs broad-spectrum topical sun protection agent (C) with activity against UVA and UVB 14. DIAGNOSTIC AGENTS 14.1 Ophthalmic drugs fluorescein sodium *tropicamide 14.2 Radiocontrast media barium sulfate *iopanoic acid *meglumine amidotrizoate

cream, lotion or gel.

eye drops, 1%. eye drops, 0.5%. aqueous suspension. tablet, 500 mg. injection, 140-420 mg iodine/ml in 20-ml ampoule.

*propyliodone oily suspension, 500-600 mg/ml in 20-ml ampoule*. *This suspension is for administration only into the bronchial tree. injection, 140-420 mg of iodine/ml in 20-ml *sodium amidotrizoate ampoule. Complementary drug(s) *meglumine iotroxate (C) solution, 5-8 g iodine in 100-250 ml. 15. DISINFECTANTS AND ANTISEPTICS 15.1 Antiseptics *chlorhexidine digluconate *povidone-iodine 15.2 Disinfectants *chlorine base compound *chloroxylenol glutaral 16. DIURETICS *amiloride hydrochloride *furosemide *hydrochlorothiazide spironolactone Complementary drug(s) *mannitol 17. GASTROINTESTINAL DRUGS 17.1 Antacids and other antiulcer drugs aluminium hydroxide *cimetidine magnesium hydroxide 17.2 Antiemetic drugs metoclopramide hydrochloride *promethazine hydrochloride 17.3 Antihaemorrhoidal drugs

solution, 5% concentrate for dilution. solution, 10%. powder for solution 0.1% available chlorine. solution, 5%. solution, 2%. (4, 7, 8) tablet, 5 mg. tablet, 40 mg; injection, 10 mg/ml in 2-ml ampoule. tablet, 25 mg, 50 mg. tablet, 25 mg. injectable solution, 10%, 20%.

(8) (C)

tablet, 500 mg; oral suspension, 320 mg/5 ml. tablet, 200 mg; injection, 200 mg in 2-ml ampoule. oral suspension, 550 mg of magnesium oxide/10 ml. tablet, 10 mg; injection, 5 mg/ml in 2-ml ampoule. tablet, 10 mg, 25 mg; elixir or syrup, 5 mg/5 ml; injection, 25 mg/ml in 2-ml ampoule.

*local anaesthetic, astringent and antiinflammatory drug 17.4 Anti-inflammatory drugs hydrocortisone 17.4 Anti-inflammatory drugs hydrocortisone acetate *sulfasalazine 17.5 Antispasmodic drugs *atropine sulfate 17.6 Laxatives *senna 17.7 Drugs used in diarrhoea 17.7.1 Oral rehydration (2)

ointment or suppository. retention enema. suppository, 25 mg. tablet, 500 mg; suppository 500 mg; retention enema. tablet, 0.6 mg; injection, 1 mg in 1-ml ampoule. tablet, 7.5 mg (sennosides) (or traditional dosage forms).

powder, 27.9 g/l; Components to reconstitute 1 litre of glucoseelectrolyte solution: oral rehydration salts (for glucose-electrolyte solution) sodium chloride 3.5 g/l; trisodium citrate dihydrate* 2.9 g/l; potassium chloride 1.5 g/l; glucose, anhydrous 20.0 g/l. *Trisodium citrate dihydrate may be replaced by sodium bicarbonate (sodium hydrogen carbonate) 2.5g/l. However, as the stability of this latter formulation is very poor under tropical conditions, it is only recommended when manufactured for immediate use. 17.7.2 Antidiarrhoeal (symptomatic) drugs *codeine phosphate (1a) tablet, 30 mg. 18. HORMONES, OTHER ENDOCRINE DRUGS AND CONTRACEPTIVES 18.1 Adrenal hormones and synthetic substitutes *dexamethasone *dexamethasone disodium phosphate hydrocortisone sodium succinate *prednisolone Complementary drug(s) fludrocortisone acetate 18.2 Androgens Complementary drug testosterone enantate 18.3 Contraceptives 18.3.1 Hormonal contraceptives *ethinylestradiol + *levonorgestrel *ethinylestradiol + *norethisterone *ethinylestradiol + *levonorgestrel *levonorgestrel medroxyprogesterone acetate norethisterone enantate 18.3.2 Intrauterine devices (C) (B) (B) (7, 8) (B) (7, 8)

tablet 500 micrograms, 4 mg. injection 4 mg of dexamethasone phosphate in 1-ml ampoule. powder for injection, 100 mg of hydrocortisone in vial. tablet 1 mg, 5 mg. tablet, 100 micrograms.

(C)

(C) (2)

injection, 200 mg in 1-ml ampoule.

tablets 30 micrograms + 150 micrograms. tablet, 35 micrograms + 1.0 mg. 50 micrograms + 250 micrograms (pack of four). tablets, 30 micrograms. depot injection, 150 mg/ml in 1-ml vial. oily solution, 200 mg/ml in 1-ml ampoule.

copper-containing device 18.3.3 Barrier methods condoms with or without spermicide (nonoxinol) diaphragms with spermicide (nonoxinol) 18.4 Estrogens *ethinylestradiol 18.5 Insulins and other antidiabetic agents *glibenclamide insulin (soluble) intermediate-acting insulin (compound insulin zinc suspension) metformin 18.6 Ovulation inducers *clomifene citrate (2, 8) 18.7 Progestogens norethisterone Complementary drug(s) medroxyprogesterone acetate (B) 18.8 Thyroid hormones and antithyroid drugs levothyroxine sodium potassium iodide *propylthiouracil 19. IMMUNOLOGICALS

tablet, 10 micrograms, 50 micrograms. tablets, 2.5 mg, 5 mg. injection, 40 IU/ml in 10-ml vial, 100 IU/ml in 10ml vial. injection, 40 IU of insulin/ml in 10 ml vial; 100 IU of insulin/ml in 10 ml vial. tablet, 500 mg. tablet, 50 mg. tablet, 5 mg. tablet, 5 mg. tablet, 50 micrograms, 100 micrograms. tablet, 60 mg. tablet, 50 mg.

19.1 Diagnostic agents All tuberculins should comply with the WHO Requirements for Tuberculins (Revised 1985). WHO Technical Report Series, No. 745, 1987, Annex 1. tuberculin, purified protein derivative (PPD) injection. 19.2 Sera and immunoglobulins* All plasma fractions should comply with the WHO Requirements for the Collection, Processing and Quality Control of Blood, Blood Components and Plasma Derivatives (Revised 1992). WHO Technical Report Series, No. 840, 1994, Annex 2. anti-D immunoglobulin (human) injection, 250 micrograms in single-dose vial. antiscorpion sera *antitetanus immunoglobulin (human) antivenom serum diphtheria antitoxin immunoglobulin, human normal immunoglobulin, human normal *rabies immunoglobulin 19.3 Vaccines 19.3.1 For universal immunization BCG vaccine (dried) diphtheria-pertussis-tetanus vaccine diphtheria-tetanus vaccine hepatitis B vaccine measles vaccine measles-mumps-rubella vaccine poliomyelitis vaccine (inactivated) poliomyelitis vaccine (live attenuated) (2) (2, 8) injection. injection, 500 IU in vial. injection. injection, 10,000 IU, 20,000 IU in vial. intramuscular injection. intravenous injection. injection, 150 IU/ml.

injection. injection. injection. injection. injection. injection. injection. oral solution.

tetanus vaccine tetanus-diphtheria (Td) 19.3.2 For specific groups of individuals influenza vaccine meningococcal vaccine rabies vaccine rubella vaccine typhoid vaccine

injection. injection. injection. injection. injection (in cell culture). injection. injection.

yellow fever vaccine injection. 20. MUSCLE RELAXANTS (PERIPHERALLY ACTING) AND CHOLINESTERASE INHIBITORS *alcuronium chloride (2) injection, 5 mg/ml in 2-ml ampoule. *neostigmine bromide tablet, 15 mg. injection, 500 micrograms in 1-ml ampoule; 2.5 mg *neostigmine metilsulfate in 1-ml ampoule. pyridostigmine bromide (2, 8) tablet, 60 mg; injection, 1 mg in 1-ml ampoule. injection, 50 mg/ml in 2-ml ampoule; powder for suxamethonium chloride (2) injection. Complementary drug(s) vecuronium bromide (C) powder for injection, 10 mg in vial. 21. OPHTHALMOLOGICAL PREPARATIONS 21.1 Anti-infective agents *gentamicin sulfate *idoxuridine silver nitrate *tetracycline hydrochloride 21.2 Anti-inflammatory agents *prednisolone sodium phosphate 21.3 Local anaesthetics *tetracaine hydrochloride 21.4 Miotics and antiglaucoma drugs acetazolamide *pilocarpine hydrochloride *pilocarpine nitrate *timolol maleate 21.5 Mydriatics atropine sulfate Complementary drug(s) epinephrine hydrochloride (A) 22. OXYTOCICS AND ANTIOXYTOCICS 22.1 Oxytocics *ergometrine hydrogen maleate oxytocin 22.2 Antioxytocics *salbutamol sulfate (2) tablet, 200 micrograms; injection, 200 micrograms in 1-ml ampoule. injection, 10 IU in 1-ml ampoule. tablet, 4 mg of salbutamol; injection, 50 micrograms of salbutamol/ml in 5-ml ampoule. parenteral solution.

solution (eye drops), 0.3%. solution (eye drops), 0.1%; eye ointment, 0.2%. solution (eye drops), 1%. eye ointment, 1%. eye drops, 0.5%. solution (eye drops), 0.5%. tablet, 250 mg. solution (eye drops), 2%, 4%. solution (eye drops), 2%, 4%. solution (eye drops), 0.25%, 0.5%. solution (eye drops), 0.1%; solution 0.5%, 1%. solution (eye drops), 2% of epinephrine.

23. PERITONEAL DIALYSIS SOLUTION intraperitoneal dialysis solution (of appropriate composition) 24. PSYCHOTHERAPEUTIC DRUGS 24.1 Drugs used in psychotic disorders

*chlorpromazine hydrochloride *fluphenazine decanoate *fluphenazine enantate *haloperidol 24.2 Drugs used in mood disorders (5) (5)

tablet, 100 mg; syrup, 25 mg/5ml; injection, 25 mg/ml in 2-ml ampoule. injection, 25 mg in 1-ml ampoule. injection, 25 mg in 1-ml ampoule. tablet, 2 mg, 5 mg; injection, 5 mg in 1-ml ampoule.

24.2.1 Drugs used in depressive disorders *amitriptyline hydrochloride tablet, 25 mg. 24.2.2 Drugs used in bipolar disorders carbamazepine (10, 11) scored tablet, 100 mg, 200 mg. lithium carbonate (2, 4) capsule or tablet, 300 mg. sodium valproate (7, 11) enteric coated tablet, 200 mg, 500 mg. 24.3 Drugs used in generalized anxiety and sleep disorders *diazepam (1b) scored tablet, 2 mg, 5 mg. 24.4 Drugs used for obsessive compulsive disorders and panic attacks clomipramine hydrochloride capsules, 10 mg, 25 mg. 25. DRUGS ACTING ON THE RESPIRATORY TRACT 25.1 Antiasthmatic drugs *aminophylline *beclometasone dipropionate *epinephrine hydrochloride *epinephrine hydrogen tartrate *ipratropium bromide

(2)

injection, 25 mg/ml in 10 ml ampoule. inhalation (aerosol), 50 micrograms per dose; 250 micrograms per dose. injection, 1 mg of epinephrine in 1-ml ampoule. injection, 1 mg of epinephrine in 1-ml ampoule. inhalation, 20 micrograms/metered dose. tablet, 2 mg, 4 mg of salbutamol; inhalation (aerosol), 100 micrograms of salbutamol per dose; syrup, 2 mg of salbutamol/5 ml; injection, 50 micrograms of salbutamol/ml in 5-ml ampoule; respirator solution for use in nebulizers, 5 mg of salbutamol/ml. tablet, 100 mg, 200 mg.

*salbutamol sulfate

*theophylline (10, 11) Complementary drug(s) *sodium cromoglicate (B) inhalation (aerosol), 20 mg per dose. 25.2 Antitussives *dextromethorphan hydrobromide (1a) oral solution, 3.5 mg/5 ml. 26. SOLUTIONS CORRECTING WATER, ELECTROLYTE AND ACID-BASE DISTURBANCES 26.1 Oral oral rehydration salts (for glucose-electrolyte solution) potassium chloride 26.2 Parenteral glucose glucose with sodium chloride potassium chloride (2)

see section 17.7.1. powder for solution. injectable solution, 5% isotonic, 50% hypertonic. injectable solution, 4% glucose, 0.18% sodium chloride (equivalent to Na+ 30 mmol/l, Cl- 30 mmol/l). solution, 11.2% in 20-ml ampoule, (equivalent to K+ 1.5 mmol/ml, Cl- 1.5 mmol/ml). injectable solution, 0.9% isotonic (equivalent to Na+ 154 mmol/l, Cl- 154 mmol/l); injectable solution, 0.18% (Na+ 30 mmol/l, Cl- 30 mmol/l) + glucose, 4%. injectable solution, 1.4% isotonic (equivalent to Na+ 167 mmol/l, HCO3- 167 mmol/l); solution, 8.4% in 10-ml ampoule (equivalent to NA+ 1000 mol/l,

sodium chloride sodium hydrogen carbonate

HCO3- 1000 mol/l). 26.2 Parenteral *sodium lactate (compound) 26.3 Miscellaneous water for injection 27. VITAMINS AND MINERALS ascorbic acid *ergocalciferol injectable solution. 2-ml, 5-ml, 10-ml ampoules. tablet, 50 mg. capsule or tablet, 1.25 mg (50,000 IU); oral solution, 250 micrograms/ml (10,000 IU/ml). iodized oil: oral solution, 0.5 ml (240 mg of iodine/ml), 1 ml (480 mg iodine/1 ml) in ampoule; injection, 0.5 ml (240 mg of iodine/ml), 1 ml (480 mg iodine/1 ml) in ampoule; solution, 0.57 ml (308 mg iodine) in dispenser bottle; capsule, 200 mg. tablet, 50 mg. tablet, 25 mg. sugar-coated tablet, 10,000 IU (5.5 mg) of retinol; capsule, 200,000 IU (110 mg) of retinol; oral oily solution 100,000 IU/ml of retinol in multidose dispenser; water-miscible injection 100,000 IU (55 mg) of retinol in 2-ml ampoule. tablet, 5 mg. in any appropriate formulation. tablet, 50 mg. (C), (2, 8) injection, 100 mg/ml in 10-ml ampoule.

iodine

(8)

*nicotinamide pyridoxine hydrochloride

*retinol palmitate

riboflavin *sodium fluoride thiamine hydrochloride Complementary drug(s) calcium gluconate