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May, 2009
May, 2009
May, 2009
May, 2009
May, 2009
Granular cells
3)Renal circulation
Constant Myogenic
(22%)
Autoregulation of RBF
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i.Proximal tubule
180L/day
1.5L/day
Reabsorption: 67% Na+,Cl-,K+,H2O; 85% HCO3-; all glucose, aa Secretion: H+ H+ -Na+ exchange Descending thin limb Ascending limb
H2O passive reabsorption through tight junction Impermeable to H2O ; Na+-2Cl--K+symporter
16
May, 2009
Na+ reabsorption
(Acid-base balance)
H2O
reabsorption(10%-15%)
17
600
400
400 600
May, 2009
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May, 2009
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The processes responsible for the uptake of Na+ and Cl- in the thick ascending limb of the loop of Henle tubule:
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May, 2009
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May, 2009
Na+ Renin secrection Angiotension II, III production Aldosterone release Na+ channel(P cells) Na+reabsorption Na+,K+-ATPase ATPase K+secrection
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May, 2009
The control of H2O uptake by ADH in the distal tubule and collecting duct:
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Blood volume Barorecptor Vagus nerve V Center Symp. nerve + Vagus nerve _ Blood pressure
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_ _
+ Osmoreceptor
ADH secretion Urine volume Blood volume Osmotic pressure
May, 2009
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Water diuresis
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May, 2009
600
400
400 600
Cortex
Collecting Duct
Medulla
Small Volume Concentrated Urine Large Volume Dilute Urine
32
May, 2009
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Role of vasa recta for maintaining the high solute concentration of renal medulla Countercurrent exchange
34
May, 2009
(negative feedback)
Na+-conserving system
ANP
Angiotensin
II
ADH
Na+,H2O excretion
Aldosterone
36
May, 2009
ANP
Angiotensin
II
ADH
Na+,H2O excretion
Aldosterone
37