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Baffles for reducing vortexing. Impellers for different flow patterns inside fermentor Multiple impellers in tall fermentors, to improve mixing
70-80% of the volume of stirred reactors is filled with liquid Adequate headspace for
disengagement of droplets from the exhaust gas accommodating any foam which may develop
Aspect ratio: Ratio of height to diameter Internal cooling coils: For temperature control and heat transfer Used for free- and immobilised cells
Generally cylindrical vessels with height > twice the diameter A sparger for entry of compressed air Typically, no internal structures. For industrial production of bakers yeast, beer and vinegar (H:D ratio of ~ 3:1 to 6:1) For treatment of wastewater.
Patterns of liquid flow are more defined Physical separation of up-flowing and down-flowing streams.
Gas is sparged into part of the vessel cross-section called Riser. Gas hold-up and decreased fluid density cause liquid in the riser to move upwards. Gas disengages at the top of the vessel leaving heavier bubble-free liquid to recirculate through the downcomer. Liquid circulation is a result of density difference between riser & downcomer.
Internal-loop ALRs
Riser and downcomer are separated by an internal baffle or draft tube Air may be sparged into either draft tube or annulus
So, gas disengagement is more effective Density difference between fluids in the riser and downcomer is greater So, circulation of liquid is faster. Thus, mixing is better in external-loop than internal-loop ALRs
In production of SCP For plant and animal cell culture In municipal and industrial waste treatment. Height of ALRs is typically ~10 times the diameter For deep-shaft systems, H / D ratio, increased up to 100.
Operated with liquid recycle Catalyst is prevented from leaving the column by screens at the liquid exit.
Particles should be relatively incompressible and able to withstand their own weight in the column without deforming and occluding liquid flow. Recirculating medium, to be clean & free of debris to avoid clogging the bed.