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Friability measurements
Procedure:
1. If a single tablet weighs < 0.65 g, select 20 tablets at random.
If a single tablet weighs > 0.65 g, select 10 tablets at random.
2. Tablets are de-dusted, weighed [W
0
], placed in a Perspex drum
(Copley Friabilator) and tumbled (rotated 100 times [4min]).
3. After de-dusting they are reweighed [W].
4. PASS if <1% friability (<0.1% is a realistic goal in development). If
>1%, repeat twice. The mean weight loss of all three must be <1%
to PASS.
Learning Outcomes
Introduction to pharmacopeial quality control tests for
tablets
Understand why quality control is necessary
Understand how to plan and conduct quality control
experiments for tablets