Bio-Artificial Liver

(Extracorporeal temporary liver support devices)

Alan Golde Jr. BME181 March 18th 2013

The Liver
Lar e!t internal or an
"ro# 1.2-1.$% (3.2-3.&l'(

)e*atic cell! (he*atoc+te!( re!*on!i'le for

liver f,nction!
Ma%e ,* 80- of the liver

Liver i! re!*on!i'le for ,* to .00 !e*arate

f,nction!
/e#ovin 0e1cretin 'od+ 2a!te! and hor#one! a!

2ell a! dr, ! and other forei n !,'!tance! 3+nthe!i4in *la!#a *rotein!5 incl,din tho!e nece!!ar+ for 'lood clottin )el*in the 'od+ fi ht infection 6rod,cin 'ile to aid in di e!tion 3torin certain vita#in!5 #ineral!5 and !, ar!

/e enerative
/e!toration of f,nction not ori inal for#

7o#*lication!
Mo!t co##on ca,!e! of liver fail,re he*atiti! A5B57585E Alcohol da#a e "att+ liver 7irrho!i! 7ancer and dr, da#a e

Treat#ent!
Liver Tran!*lant
6ro! Mo!t effective treat#ent for ac,te liver fail,re )i h !,rvival rate! 7on! 3carcit+ of donor! /ed,ced clottin factor! 9##,no!,**re!!ant:! increa!e ri!% for infection /e;ection

Bio-artificial Liver
6ro! <ee* the *atient alive ,ntil tran!*lant i! availa'le Aid in the liver! re eneration 7on! Are onl+ a te#*orar+ fi1

7,rrent =or% in BAL>!

Molec,lar A'!or'ent /ec+clin 3+!te# (MA/3?(
Tera%lin5 ,!e! h,#an al',#in

E1tracor*oreal Liver A!!i!t 8evice (ELA8?(

@ita en5 ,!e! i##ortali4ed h,#an he*atoc+te!

)e*atA!!i!t 2000 !+!te#

7irce Bio#edical5 ,!e! *orcine he*atoc+te!

Bioartificial Liver 3,**ort 3+!te# (BL33?(

E1cor* Medical5 9nc.5 ,!e! *ri#ar+ *orcine he*atoc+te!

L9@E/A2000 !+!te#
Al eni15 9nc.5 ,!e! *orcine he*atoc+te!

Mod,lar E1tracor*oreal Liver 3+!te# (MEL3?(

7harite @ircho2 7linic-Berlin5 ,!e! h,#an he*atoc+te!

Bio En ine! 9#*lanta'le 8evice

8e!i ned to ta%e *lace of a liver or a

*ortion of the liver 6ol+#er rid-li%e #e!h ,!ed a! artificial va!c,lat,re re!e#'lin that of an act,al liver 6atterned !ilicon 2afer! !erve a! #old! for *ol+#er !heet! 7,rrentl+ 'ein te!ted on *i ! 7lottin i!!,e!

7hallen e!
Bio-artificial liver! !ho,ld 'e a'le to *rovide at lea!t 10- of liver f,nctionin
Thi! reB,ire! a**ro1i#atel+ 1010 he*atoc+te!

@er+ diffic,lt acB,irin thi! #an+ he*atoc+te cell! 7ontrover!+ over the ,!e of *orcine cell! d,e to *o!!i'le tran!#i!!ion of

infection! )e*atoc+te! and *la!#a have ver+ different *h+!io-che#ical *ro*ertie!

)e*atoc+te! do not *erfor# 2ell 2hen in contact 2ith *la!#a )ave a ver+ hi h o1+ en ,*ta%e rate

)e*atoc+te cell! ,nder o a lot of !tre!! in!ide of 'io-artificial liver

An+ !tre!! a'ove . d+n0c# 2 render! cell! ,!ele!!

Li#ited vol,#e of the 'ioreactor

#a1i#,# 'lood0*la!#a that can 'e !afel+ dra2n o,t of liver fail,re *atient i! one liter 8iffic,lt to achieve 10- of liver f,nctionin 2ithin 1 liter

Ma%e! Bio-artificial liver de!i nin ver+ diffic,lt

",t,re
/e!earch inC 7ell !o,rce! Bioreactor de!i n "ilterin techniB,e! 6ac%a in for i#*lanta'le device!

3o,rce!

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