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Levels of fasting blood glucose (p<0.0001),
glycosylated hemoglobin (p<0.0001),
triacylglycerol (p<0.001) were significantly raised
and HDL cholesterol (p<0.001) was significantly
decreased in diabetes cases with or without
complications when compared with controls. In
patients with complications, along with these
levels , total cholesterol (p<0.001) and low density
lipoprotein cholesterol (p<0.001) were also
significantly raised and high density lipoprotein
cholesterol (p<0.0001) significantly decreased.
There is a definite positive correlation of
glycosylated hemoglobin with the levels of total
cholesterol, triacylglycerol, and low density
lipoprotein cholesterol in both the study groups
and a negative correlation with high density
lipoprotein cholesterol.

CONCLUSION
REFERENCES






N.M. Naseb
2
, J.R. Peela
1
, S. Shakila
1
, A.R. Said
1
, L.T. Peela
4
, R.N. Yedla
3
AM Jarari
2
S. D. Kolla
3,
, L. T. Peela
4,
, S. J. Dhoipode
5

1.Department of Biochemistry, Faculty of Medicine,University of Benghazi, Benghazi, Libya.
2. Department of Biochemistry,Faculty of Medicine,Quest International University Perak, Ipoh, Malaysia,
3. Department of Biochemistry,Rangaraya Medical College,, Kakinada, India,
4. Great Eastern Medical School, Srikakulam, India
5. Department of Pharmacology, Guardian college of Dental Sciences and research centre,Ambernath,Thane,Maharastra,India.



CORRELATION BETWEEN GLYCATED HEMOGLOBIN AND SERUM LIPIDS IN TYPE 2 DIABETICS IN EASTERN
LIBYA.
Logo
Here
60 subjects have been chosen for this
study comprising of 20 healthy controls,
40 subjects were diagnosed with diabetes
mellitus, 20 with and another 20 without
any vascular complications respectively.
Fasting blood samples of all the cases and
controls were tested for glucose levels,
glycosylated hemoglobin, total cholesterol,
triacylglycerol and HDL cholesterol using
authenticated reagent kits. LDL cholesterol
was calculated using Friedwalds
formula.
MATERIALS AND METHODS
RESULTS
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From the results obtained in our study, it can be
inferred that there is a positive correlation
between the glycosylated hemoglobin value
and serum lipoproteins which strongly
suggests dyslipidemia in diabetic patients when
not under control. Measurement of glycosylated
hemoglobin is more relevant than fasting blood
glucose for the evaluation of diabetes mellitus
and its complications.

Table.1 Controls
Table.2 Diabetics without complications
Table.3 Diabetics with complications
FBS HbA1c TC LDL HDL TGs
Mean
90.7 5.64 124.65 70.70 46.15 136.60
STD
13.85 1.66 29.16 29.68 18.58 39.83
FBS HbA1c TC LDL HDL TGs
Mean
158.95 9.23 150.2 67.90 35.65 163.6
STD
39.99 2.26 52.62 42.18 8.66 82.25
t-test
-7.298 - 6.720 -1.825 0.223 2.44 -1.162
p-
Value
<
0.0001
<
0.0001
0.084 0.826
<
0.001
<
0.001
signifi
cance
H.S



FBS HbA1c TC LDL HDL TGs
Mean
191.85 8.86 171.2 106.30 28.10 162.7
STD

56.053
1.62

47.246
39.45 5.37 59.54
t-test
-7.657 - 5.459 - 3.733 -3.938 4.129 -3.291
p-
Value
<
0.0001
<
0.0001
< 0.001 < 0.001 < 0.001 < 0.001
Signifi
cance
H.S



Prevalence of diabetes mellitus is a
global problem and Libya is no exception
to this problem particularly due to a raised
incidence of metabolic syndrome, genetic
predisposition and their dietary habits.
Complications of diabetes includes
cardiac, renal, ophthalmic and other
vascular complications due to
atherosclerosis.
Present study evaluates the status of
serum lipoproteins in diabetics with and
without complications in correlation with
HbA
1
C.
INTRODUCTION