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Classification of Non-Hodgkin
Lymphoma
Classification of Non-Hodgkin
Lymphoma (selected common entities)
Precursor B cell
Acute lymphoblastic
lymphoma
Peripheral B cell
Small lymphocytic
lymphoma SLL, Chronic
lymphocytic leukemia CLL
Mantle cell lymphoma
Follicular lymphoma
Marginal zone lymphoma
Diffuse large B cell
lymphom
Burkitt lymphoma
Precursor T cell
Acute lymphoblastic
lymphoma
Peripheral T cell
Anaplastic large T cell
lymphoma
Peripheral T cell lymphoma
B cell
Precursor
Nave
Morphology
Blast
Small mature
Markers
CD34/TdT
Homing
BM
CD5
Peripheral
Symptoms
BM suppression
Patterns
Mantle
Large transformed
plasma cell
CD20/CD10
CD20 only
LN
Leukemia
LN/extralymphatic
LN involve
mass
Acute lymphoblastic
lymphoma/leukemia (ALL)
Clinical: children, young adults, leukemic,
mediastianl mass (T cell ALL), Bone
marrow involvement, high grade
Pathology: medium size Blasts, uniform
Immuno: TdT, CD 34, CD10, (CD20 or
CD3)
Follicular lymphoma
Clinical: Low grade, Nodal, > 40 years
Pathology: large malignant follicles,
mixture of small (centrocytes) and large
cells (centroblasts)
Immuno: CD20, CD10, Bcl-2
T(14;18) Bcl-2 over expression
30% transform to large cell lymphoma
Burkitt lymphoma
Clinical: 3 types
1. Endemic: African EBV
2. Sporadic: North America
3. Immunosuppressed (HIV)
Aggressive tumor
Pathology: medium size, high mitosis, apoptosis,
Starry sky pattern
Immuno: CD20, CD10
T(8;14) C-myc over expression
Test