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HDL
ApoA1-Milano
in
atherosclerosis
By Padminee Krishnan
3 rd year BDS
ApoA1
mutation
ApoA1Milano
ATHEROSCLEROSIS
Atherosclerosis is a specific form of
atheromas
An atheromatous plaque consists of a raised
STAGES OF
ATHEROSCLEOSIS
FREE
RADICALS
(NO, ROS,etc)
Lipid laden
monocytes
FOAM CELLS
oxidation
Monocyte
Ox-LDL
Scavenger
receptors
The
monocyte
engulfs the
lipid particles
anti-atherogenic
Normal value -30 to 60 mg/dl
LDL- transports cholesterol from liver to peripheral tissues
oxidized LDL is responsible for formation of foam cells
normal value - 80 t0 175mg/dl
Patient with
TG
low HDL,
high triglycerides
but no signs of pathology?!?!
ApoA1- Milano
ApoA1-Milano is a naturally occurring mutant
variant of ApoA1 of human HDL
The ApoA1-Milano mutation was found by
University of Milan
It was discovered that this mutant variant was
present in 3.5% of the local population of
Limone, a small village in Northern Italy
ApoA
1
aa
Point
aa
aa
173
aa
ApoA1Milano
Argi
nine
aa
Cyst
eine
173
mutation
In ApoA1
peptide
aa
aa
of
Human
HDL
bridge formation
This restricts the size and growth of HDL attributing to
LDL
Prevents
oxidation of
LDL
mops up
unpaired
electrons
Free
radica
ls
ApoA1Milano
in
HDL
FUTURE SCOPE
Having known the new activity associated
CONCLUSION
Study of literature says that the carriers of
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