Acquired immunity

(sistem imun didapat)

Afiana Rohmani

Sistim imun
LIMFOSIT sel berperan utama dalam
sistem imun spesifik.
Limfosit sel T : imunitas seluler
Limfosit Sel B : imunitas humoral

RESEPTOR

Sel B : BCR antibodi

Sel T : TCR mengenal antigen yang diikat
MHC

Immunocompetence

T and B cells that have not been exposed

to an antigen are naif.

Binding with an antigen completes

differentiation into functional B and T cells.

Immunological memory

Primary immune
response

Secondary
immune response

Antibody production

MHC II + Ag
Antigen

CD4

Antigen is presented by macrophage and

B cell to CD4 T cell which in turn release
cytokines for B cell activation and
antibody production

Antibody production

Plasma
cell
IL- 3,4,5,6, GM-CSF

MHC II + Ag
Antigen

CD4

Antigen is presented by macrophage and

B cell to CD4 T cell which in turn releases
cytokines for B cell activation and
antibody production

Antibody production
IL- 4
IgE

IL- 5,
TGF

IgA

B
IL- 4, 5

The influence of cytokines on

Immunoglobulins synthesis

IgM
IL- 4,5,6,
IFN

IgG

CELLULAR MEDIATED
IMMUNITY

CD4

Intracellular
microbes
Macrophage

IFN-gamma
CD4 Th1

Macrophage presents the antigen in

association with MHCII to CD4 T cell

CELLULAR MEDIATED
IMMUNITY

IFN

CD4

Intracellular
microbes

IL-1

CD4 Th1 cell produces IFN for

Macrophage macrophage activation
IFN-gamma
CD4 Th1

CELLULAR MEDIATED
IMMUNITY

IFN

CD4

Intracellular
microbes
Macrophage

IFN-gamma
CD4 Th1

IL-1

CELLULAR MEDIATED
IMMUNITY

IFN

CD4

Intracellular
microbes

IL-1

CD4 Th1 cell can also produce ILMacrophage 2, and along with IFN contribute
the differentiation of CD8 T cell to
Cytotoxic T Lymphocyte (CTL) to
IFN-gamma kill tumor cells or virally infected
cells
CD4 Th1

IL-2 , IFN

CD8

CELLULAR MEDIATED
IMMUNITY

IFN

CTL

CD4

IL-2 , IFN

CD8

CTL
CTL

Intracellular
microbes

IL-1

CD4 Th1 cell can also produce ILMacrophage 2, and along with IFN contribute
the differentiation of CD8 T cell to
Cytotoxic T Lymphocyte (CTL) to
IFN-gamma kill tumor cells or virally infected
cells
CD4 Th1

CTL

CELLULAR MEDIATED
IMMUNITY
CTL / CD8 killing activities
Antigen
expressed

Target
cell

CD8

Virus

Granzyme

Perforine
MHC I + Antigen

Tumor cell / virally infected cell /

transplant cell

CELLULAR MEDIATED
IMMUNITY
CTL / CD8 killing activities

Virus released and dies

CD8

Virus

Granzyme

cell lysis
Perforine

Tumor cell / virally infected cell /

transplant cell

The pathways of immune response

Internet
File

Respon imun spesifik

Sistem humoral
- Diperankan oleh limfosit B
- Rangsangan antigen sel B proliferasi &
diferensiasi sel plasma membentuk antibodi
- Pertahanan thd bakteri ekstra seluler, netralisir
toksin
Sistem seluler
- Diperankan oleh limfosit T : Th, Tc,
- pertahanan thd bakteri intraseluler, virus, jamur,
parasit, keganasan
Antibody dependent cellular immune respons
sel null sel K

The roles of MHC / HLA genes on the activation of immunity

HLA ( Human Leucocyte Antigen )

DMB
G
H

DMA

DQB

DRB
DQA

TNF

DRA

APC
HLA Class II : reacts with the
CD4 molecule on the T helper
cell (important for antigen
presentation by APC)
HLA Class I : reacts with the
CD8 molecule on the
Tcytotoxic lymphocyte (Tc)
(important for Tc mediated
cell lysis)

CD4

T
Infected
cell

CD8

C E A

SEL T
Dibentuk di sumsum tulang, pematangan di timus
Mempunyai petanda permukaan membedakan dg sel B
pemeriksaan rosette (+)
Mempunyai petanda CD (cluster differentiation) sel T
dlm berbagai fase pertumbuhan
Fungsi :
membantu sel B dlm memproduksi antibodi
mengenal & menghancurkan sel yang terinfeksi virus
mengaktifkan makrofag dlm fagositosis
mengontrol ambang & kualitas sistem imun
Jenis : sel Th (helper), Tc (cytotoxic) ,Ts (supresor), Td
(delayed hypersensitivity)

SEL B

Dibentuk & dimatangkan di sumsum tulang

Proses pematangan sel asal pre B sel B

imatur
sel B matur proliferasi & diferensiasi
sel plasma antibodi /Ig (imunoglobulin)

Rangsangan antigen I terbentuk IgM

Selanjutnya akan terjadi switching Ig A, Ig E. Ig
D, Ig G

Terima kasih