LYMPHATICSYSTEM

MariebChapter20

LymphaticSystem

capillaries
ducts
nodes
lymphoidorgans
diffusecellpockets

Lymphaticcapillaries
extremelypermeable
presentthroughoutbody
interminglewithblood
capillaries
notinCNSormineralized
tissues

Lymphatic
Ducts
Trunks

Lumbar
Bronchomediastinal
Subclavian
Jugular
Intestinal

 Trunksanastomose&
enterveinousreturnat
junctionofsubclavian
&jugularveins

LymphVesselStructure
muchlikeveins
morevalves
morefrequent
anastomoses

ELEPHANTIASIS
Atropicaldiseasecausedby
lymphaticobstruction.
Victimisbittenbya
mosquitoinfectedwitha
roundwormknownasa
filarialworm.
Theresultingedemaleadsto
fibrosisandelephantlike
thickeningoftheskin.

Lymphoid
organs

LymphNodes
Encapsulatedby
densefibrous
connectivetissue
Trabeculae
capsuleextends
inwardform
compartments

LymphNodes
Clustersatjunctions
ofvesselsinto
trunks

Lymphnode
structure
Figure20.4a

Cortex
densefollicleswithgerminalcenters
dividingBcells
Deepcortex(Tcells)

Medulla
inwardextensionsofcorticaltissue(B,Tandplasmacells)

Sinuses
lymphdrainage
filteredbymacrophages

Circulationinthenode:
afferentlymphaticvesselsubcapsularsinusdrainthroughtissuehilus
efferentvessels

LymphoidOrgans

Spleen

Spleen

Thymus
primaryfunctionisinearlylife
SecretesthymosinandthymopoietinwhichcausesTlymphocytes
tobecomeimmunocompetent
LacksBcells(nofollicles)
Atrophieswithage:prominentinnewborns,stopsgrowthby
adolescence,degeneratesbyoldage

Thymus

LymphoidFollicleAggregates
MALT(mucosaassociatedlymphatictissue)includes:

PeyersPatchesinintestines
Appendix
Tonsils
Smallbronchiolarfollicles

MALTarepositionedwellto:
Destroybacteriathatbreachthemucosalmembranefromoutside
Developmemorylymphocytesforlongtermimmunity

Tonsils

Tonsils
notencapsulated
blindpouchescrypts
bacteriacanenter
inducedimmuneresponse

PeyersPatches

PeyersPatches