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FK UNSWAGATI
Indriani Silvia
Hematopoiesis
sistem
biologi
sel
stem
yang
meliputi interaksi seluler dalam
perkembangannya dan homeostasis
jaringan, siklus turunan sel stem,
dan reaksi transkripsi (pengulangan
siklus) dengan beragam fenotipe
seluler yang spesifik (berdasarkan
tahapannya).
1.
2.
AGE
Fetus: 0-2 months
SITE
Yolk sac
2-7 months
Liver, spleen
5-9 months
Bone marrow
Infants
Adults
PPSC
Early
Proerythroblast
Intermediate
Polychromatophilic
erythroblast
Basophilic
erythroblast
Late
Reticulocyte
Orthochromatic
erythroblast
(normoblast)
Erythrocyte
Proerythroblast
(pronormoblast)
Basophilic
erythroblast
Polychromatophilic
erythroblast
Orthochromatic
erythroblast
(normoblast)
Reticulocyte
Erythrocyte
Band Stage
Kierszenbaum
Fig. 6-20;
See Ross 5th
Ed Table 10.4
1. Promyelocyte
3. Metamyelocyte
2. Myelocyte
4. Band Form
Kierszenbaum, Fig. 6-21
Myeloblast
(do not identify
in lab)
Promyelocyte
Myelocyte
Metamyelocyte
Band form
Pluripotent
stem cell
Kierszenbaum,
Fig. 6-14
Stromal
cells:
adipocytes
Fibroblast
Reticulum
cella
Endothelial
secrete
Extracellular
molecules:
Collagen
Glycoprotein
(fibronectin,
thrombospondin)
Glycosaminoglycans
(hyaluronic acid &
(& macrophages)
Stromal cells
Site of action
HGF
Stromal cell
IL-1, TNF
Embryonic SC
totipotent generate
all tissues.
Evidence adults SC
(in different organs)
pluripotent.
Bone marrow:
Hematopoietic SC
Mesenchymal SC clinical
application
th/mesenchymal disease
Control hematopoiesis by
growth factors:
Factors acts on cells
expressing the
corresponding receptors.
Binding of GF to its receptor
activates
by JAKs then phosphorylate
STATs
which translocate to the
nucleus and
activate transcription of
specific
genes
Glycoprotein
Mediate the attachment of marrow
precursors, leukocytes and platelet to
various components of the extracellular
matrix to:
Endothelium
Other surfaces
Each other