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SURFACTANTS IN
IN
SOLUTION
SOLUTION
Classification of
Surfactants
O
Anionic S - +
O Na
O
Cationic Sodium dodecylsulfate (SDS)
Zwitterionic +
Nonionic N
Br-
Cetylpyridinium bromide
O
O
O OCH2CH2N(CH3)3+
P O-
O
O
Dipalmitoylphosphatidylcholine (lecithin)
O O OH
O O
Polyoxyethylene(4) lauryl ether (Brij 30)
Surfactant Aggregates
Normal micelles
Unimers cylindrical
spherical
4 nm
Critical Micelle Concentration
CMC
14
12
10 Below CMC only
8
6
CMC
unimers are present
4
Above CMC there are
2
0 micelles in equilibrium
0 1
Surfactant concentration with unimers
Solution Properties
14 14
12
unimers 12 Osmotic pressure
Concentration
10 10
8 8
6 CMC 6 CMC
4 micelles 4
2 2
0 0
0 Surfactant concentration1 0 Surfactant concentration1
14
Isc12
10 Light scattering
8
6 CMC
4
2
0
0 Surfactant concentration1
Solubilization
Spontaneous transfer of a compound insoluble in
the bulk solvent into solution due to incorporation
into the surfactant micelles
amphiphilic compound
Solubility Effects
14
Solubility
12
10
8
6
CMC
4
2
0
0 1
Surfactant concentration
An example of an HLB value
calculation
BRIJ 98 INCI name : oleth-20 is a 20 mole
ethoxylate of oleyl alcohol
calculate the molecular weight of the 20
moles of ethylene oxide ( one mole ETO =44
);
20 x 44 = 880
add this number to the molecular weight of
the oleyl alcohol;
880+ 270 = 1150 ( the mol. wt of BRIJ 98 )
What percentage of 1150 is 880 ?
880/1150 = 76.5%
76.5% divided by 5 = 15.3
15.3 is the HLB value of BRIJ 98
Important to remember !
HLB and Use of Surfactants
Polyoxyethylenesorbitan monooleate;
Sorbitan monooleate ethoxylate
Aqua/Water
Palmitic acid
Myristic acid
Lauric acid
Stearic acid
Potassium hydroxide
PEG-7 Glyceryl cocoate
PEG-150 Distearate
Glycerin
Sodium laureth sulfosuccinate
Limonene
Linalool
Zinc PCA
Propylparaben
Propylene glycol
Disodium EDTA
NaCl
Propylene glycol