Conceptual

Production Plant
Design
 Presentation
Outline
Design Consideration
Unit Operations in
Pharmaceutical Industry
Design Consideration
3 ways selection for PP
design
Slide Rule or calculator
Spreadsheet ( Lotus or Excel)
Simulator (Superpro)
 Preparation before
design
Study about general idea in
thermodynamics and fluid
mechanics.
Study about unit operations
that concern to drug
production.
 Design Procedure
Write down flowsheet.
Put (register) elements or mixtures into unit
operations.
Insert input stream into that unit operations.
Calculate the unknown requirement after
putting known variables into the equation.
Check among
calculator,spreadsheet,simulator.
 Thermodynamics
Some definitions and physical
properties of air and heat.
Standard air
Density
Density factor
Specific heat
 Thermodynamics
(continue)
Btu. or Calorie
Heat capacity
Absolute Temperature
Latent heat
Enthalphy
Adiabatic ( No heat transfer )
Psychrometric Chart
Some equations concern
to this job
Mass Balance
Energy Balance
See examples
Equation concern to
Ideal Gas
PV = nRT
Boyles Laws
Charles Laws
 Fluid Mechanics
Different properties between
liquids and gas.
Free surface
Compressible or not
Viscosity
 Fluid Mechanics
(continue1)
Pressure = unit wt. X height of
liquids
Pressure Head = Pressure/unit
weight
gage pressure
Absolute pressure
 Fluid Mechanics
(continue2)
Continuity Equation
Bernoullis Equation
 Unit Operations
in Pharmaceutical
Industry
Well-Mixed Batch
Reactor

tz
RXN-101
hWM B
 Well-Mixed Batch
Reactor
(batch) closed vessel with stirrer &
thermal jacket
put elements or mixtures inside
put others stream
control P, T
turn-on motor for stirrer
Ultrafiltration

O-BUF-101
&Ultrafi
 Ultrafiltration
membrane process (pressure driven)
separate mixture of different MW
(proteins)
small solute molecules pass through the
membrane and are collected as permeate.
 Ultrafiltration
larger solute molecules do not pass
through the membrane are recovered in
concentrated solution
unlike RO, because membranes are too
porous to be used for desalting
 Rotary Drying

F$RDRNG-101 /
Rotar
 Rotary Dryer
Unit operation to dry materials
Mainly part consists of slightly inclined
hollow cylinder
look similar to the kiln (cement mixture
dryer)
 Reference
Hand book of Chemical
engineering.(Perry)
Units operations and
Transportation.
Sheets about Drug Production.
* Tamoxifen Production Plant.
(Introduction & Reactor Analysis)
* Develop a design example.
Thank you