Hasil Evaluasi Formula

Mucoadhesive Strength Test

Formula 1-9
Mucoadhesive Strength Test
Formula 10-18
Mucoadhesive Strength Test
Formula 19-27
 Uji In Vitro
Formula 1-7
 Uji In vitro
Formula 8-14
 Uji In vitro
Formula 14-21
 Uji In Vitro
Formula 22-27
Response Surface Plot for % cdr
Response Surface Plot for Ex Vivo
Residence Time
Response Surface Plot for
Mucoadhesive Strength
 Conclusion
Captopril sebagai tablet mukoadesif oral dapat
diformulasikan menggunakan polimer
carbopol 940p, HPMC K45 M, Na CMC.
Ketiga polimer tersebut dapat menimbulkan
efek yang sinergis jika dikombinasi.
Carbopol 940p dapat meningkatkan
pelepasan obat dan mucoadhesive strength
Dari 27 formula, formula 12 paling baik