ERYTHROPOIESIS

HEMOGLOBIN STRUCTURE AND

SYNTHESIS
LEARNING OBJECTIVES:
• Discuss the other concepts of
erythropoiesis
• Discuss hemoglobin: structure,
synthesis and function
HEMOGLOBIN
• a complex protein found in red
blood cells that carries oxygen
throughout the body
Function: carry oxygen from the
lungs to the body tissues, and to
exchange the oxygen for carbon
dioxide, and then carry the carbon
dioxide back to the lungs and
where it is exchanged for oxygen
HEMOGLOBIN
HEMOGLOBIN
+
HEME SYNTHESIS
IRON METABOLISM
 GLOBIN SYNTHESIS
TYPE OF POLYPEPTIDE
STAGE OF LIFE
HEMOGLOBIN COMBINATION
GOWER 1 2 zeta, 2 epsilon EMBRYONIC

PORTLAND 2 zeta, 2 gamma EMBRYONIC

GOWER 2 2 alpha, 2 epsilon EMBRYONIC

NEWBORN AND
FETAL 2 alpha, 2 gamma
ADULT
NEWBORN AND
A 2 alpha, 2 beta
ADULT
NEWBORN AND
A2 2 alpha, 2 delta
ADULT
HEMOGLOBIN
FUNCTION:
• Transport of molecular O2 from the lungs
to the tissues
• Transport of CO2 from the tissues to the
lungs
• Buffers the body to prevent changes in pH
incompatible to life
 FACTORS AFFECTING
HEMOGLOBIN AFFINITY FOR O2
FACTOR INCREASED DECREASED

Temperature Shift to the right Shift to the left

Blood pH Shift to the right Shift to the left

2,3 - DPG Shift to the right Shift to the left

Carbon dioxide Shift to the right Shift to the left

Hemoglobin F Shift to the left Shift to the right

Other Hemoglobin variants

Either