Esophagus (Skeletal Muscle)

Muscularis
externa – has
inner circular and
outer longitudinal
layers (but
“appears
irregularly
arranged in many
areas” – p. 45,
manual)
 mucosa

submucosa

Mucosa – stratified squamous epithelium; cells are flat but contain nuclei; deepest
layer is darkly stained and constitutes germinative layer
Submucosa – thick CT layer; contains large vessels, nerves, mucous glands
(esophageal glands)
-p. 45, manual
 Esophagus, Upper Human MCO 0069

Myenteric ganglion a.k.a. Auerbach’s

plexus – situated between circular
and longitudinal layers of muscle

vessel
Middle Esophagus (MCO 0070) low mag

“the muscularis externa of the middle esophagus contains

smooth and skeletal muscle, especially in the outer,
longitudinal layer” – p. 46
 Tunica adventitia
– loose areolar
tissue to dense
CT

mucosa
Muscle – find myenteric
ganglion here
Lamina propria submucosa
Esophageal-Stomach (cardia) junction – MCW 059

esophagus
stomach

Lymphoid
tissue

NOTE: muscularis externa of

lower esophagus is all smooth
muscle
Muscularis
externa of
stomach –
has inner
oblique,
middle
circular, and
outer
longitudinal
 Lamina
propria (has
glands)

submucosa

muscle

Muscularis
mucosa –thin -
difficult to find
MCO 071 – esophageal-stomach junction

Esophagus
Stomach
(stratified
(simple
squamous)
columnar)
Fundic stomach – MCW063 (low mag)

submucosa (see next

Layers of muscle
of muscularis two slides)
externa
No goblet
cells in
stomach

glands
Chief cells
-at base of gland
-have basophilic
zymogen granules Parietal cells (?)
-principal cell type in -eosinophilic,
basal portion of fundic -rounded
gland (p. 47, manual)
-found throughout full
extent of gland
- produce HCl and
intrinsic factor
Pyloric stomach – MCW 065 (low mag)
Pyloric portion – “long
gastric pits (2/3) and
relatively short gastric
glands (1/3)” – p. 47,
manual

pit

glands Connective tissue – has

vessels
Myenteric
plexus
Mucous neck
cells
parietal cells
-eosinophilic
-scattered in the
pyloric region
– fewer parietal
cells compared
with fundic region
 Pyloric-duodenal junction UW046

stomach
duodenum

Pyloric sphincter
Crypts of Lieberkuhn of Duodenum
Muscularis mucosae extend into villi causing contraction
Duodenum – MCW 068

submucosa
Brunner’s
glands (in
submucosa)
– function is
to secrete
alkaline fluid
to neutralize
acidic chyme
Villus
(has
lacteal)
Crypts (in
various
cuts)
Brunner’s
glands

muscle
enterocytes

Goblet cells
 Lamina
propria
with
plasma
cells

Goblet
Crypt
cells
EC cells –
difficult to find –
Dr. Howard said
don’t have to
identify on
practical (but
know for written)

Paneth cell – pink; located at

base of crypt
 Jejunum – MCW070
Plica circulares
-a.k.a. valves of
Keckring
-are “large infoldings of
the mucosa and
submucosa” –p. 49,
manual
Ileum (low mag)

Peyer’s patches (will find M

cells on lumenal side)
Ileum – MCW072 (low mag)

Submucosa – has vasculature

 Ileum - LH0131

Lacteal
 Appendix

Numerous lymphatic nodules

and diffuse lymphatic tissue
AROUND ENTIRE CIRCUMFERENCE
 Colon – LH0135 (low mag)

No villi in colon
– only has
crypts of
Lieberkuhn

Thick internal
muscle layer
Mostly goblet cells (85-
95% of epithelial cells of
colon will consist of
goblet cells) – p. 51

Vasculature
with blood
 Recto-anal junction – MCO 0079 (low mag)

Skeletal
muscle

Pectinate
line
(junction)

Epithelium - Epithelium – Epithelium – simple columnar

stratified squamous stratified squamous w/ goblet cells
keratinizing (external non-keratinizing
skin)
Junction – simple columnar (right) to
stratified squamous nonkeratinizing (left)
Junction - stratified squamous keratinizing (left) and
stratified squamous nonkeratinizing (right)
 External anal
sphincter –
skeletal
muscle

Internal anal
sphincter
(muscularis
externa – has
inner and outer
layer) – smooth
muscle
Anus and Rectum – monkey (low mag) UW2059

Muscularis
externa

Skeletal muscle